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Selected 1,3,4-Oxadiazole Analogs Acting as GSK-3β Inhibitors

16. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. 2002;298:1912-34

19. Woodgett JR, Cohen P. Multisite phosphorylation of glycogen synthase. Molecular basis for the substrate specificity of glycogen synthase kinase-3 and casein kinase-II (glycogen synthase kinase-5). 1984;788:339-47

Selected Analogs of 5-Imino-1,2,4-Thiadiazoles Acting as GSK-3 inhibitors


10. Singh V, Lin R, Yang J, Cha B, Sarker R, Tse CM. . AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking. 2014;289:5449-61

11. Song J, McColl J, Camp E, Kennerley N, Mok GF, McCormick D. . Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells. 2014;111:7337-42

Synthesis and anticancer evaluation of 1,3,4 …

14. Kuemmerle JF. Endogenous IGF-I protects human intestinal smooth muscle cells from apoptosis by regulation of GSK-3 beta activity. 2005;288:G101-G10

20. Peat AJ, Boucheron JA, Dickerson SH, Garrido D, Mills W, Peckham J. . Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors. 2004;14:2121-25

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A series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized, ..

Synthesis and Anticancer Evaluation of 1,3,4 …

8. Maurer U, Preiss F, Brauns-Schubert P, Schlicher L, Charvet C. GSK-3-at the crossroads of cell death and survival. 2014;127:1369-78

Synthesis and biological evaluation of some 1, 3, 4-thiadiazoles

23. Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. 1994;303:21-6

Theranostics 2016; 6(4):571-593

27. Beurel E, Mines MA, Song L, Jope RS. Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development. 2012;14:822-30

Synthesis of new 2,5-Disubstituted-1,3,4-thiadiazoles …

29. Li DW, Liu ZQ, Chen W, Yao M, Li GR. Association of glycogen synthase kinase-3beta with Parkinson's disease (review). 2014;9:2043-50

A Novel Series of Thiazoles and 1,3,4-Thiadiazoles …

7. Watkins CC, Sawa A, Pomper MG. Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application. 2014;4:e350

Thiadiazoles/chemical synthesis*

31. Llorens-Martin M, Blazquez-Llorca L, Benavides-Piccione R, Rabano A, Hernandez F, Avila J. . Selective alterations of neurons and circuits related to early memory loss in Alzheimer's disease. 2014;8:38

Synthesis and antimicrobial activity evaluation of new 1…

33. Llorens-Martin M, Fuster-Matanzo A, Teixeira CM, Jurado-Arjona J, Ulloa F, deFelipe J. . GSK-3 beta overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo. 2013;18:451-60

Thiophene synthesis - Organic Chemistry Portal

34. Lim NK, Hung LW, Pang TY, McLean CA, Liddell JR, Hilton JB. . Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain. 2014;23:4051-63

Thiazole synthesis - Organic chemistry

35. Zhou F, Xue M, Qin D, Zhu X, Wang C, Zhu J. . HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3beta signaling pathway. 2013;8:e53145

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