The base which draws away the hydrogen atom should be a strong base.In the removal step, the hydrogen being removed and the leaving group should be 180 degrees opposite each other, or "anti-periplanar."Attached on separate paper.(Table 01)(*More data for these compounds could not be found in the reference material.)(Table 02)With KOH:With potassium t-butoxide:The process is the same for the two different bases, except in step one of the flowchart.1) Prepare 4 M KOH in 25 mL 1-propanol. Or, if you are using potassium -butoxide, then prepare a 1 N solution of this in 25 mL 1-propanol.2) add 2.5 mL 2-bromo-2-methylbutane.3) Reflux for 45 min.
6.1 Catalytic hydrogenation converts an alkene to an alkane having the same carbon skeleton. Since 2-methylbutane is the product of hydrogenation, all three alkenes must have a four-carbon chain with a one-carbon branch. The three alkenes are therefore:
For activities in relation to consumer products the proposed Order would not apply to products to which the Canada Consumer Product Safety Act (CCPSA) does not apply (see Annex A for the CCPSA definition of “consumer product” and exemptions), with the exception of cosmetics (in some cases) within the meaning of section 2 of the Food and Drugs Act. The Order would not apply to uses of the substances that are regulated under any of the following Acts of Parliament listed in Schedule 2 of CEPA, including the Pest Control Products Act, the Fertilizers Act and the Feeds Act. The Order would also not apply to transient reaction intermediates, impurities, contaminants or partially unreacted intermediates, or in some circumstances to items such as, but not limited to, wastes, mixtures or manufactured items. However, it should be noted that individual components of a mixture may be notifiable under the Order. See subsection 81(6) and section 3 of CEPA, and section 3 of the Guidelines for the Notification and Testing of New Substances: Chemicals and Polymers for additional information on the activities and conditions described above.
8.37(a)Tertiary alkyl halides undergo nucleophilic substitution only by way of carbocations: SN1 is the most likely mechanism for solvolysis of the 2-halo-2-methylbutanes.
Assuming that the reaction of the methanesulfonate with NaSCH2CH3proceeds with 100% inversion of configuration, we conclude that the maximum rotation of sec-butyl ethyl sulfide is the value given in the statement of part (b), that is, 25°. Since the sulfide produced in part(c) has a rotation of 23°, it is 92% optically pure. It is reasonable to assume that the loss of optical purity occurred in the conversion of the alcohol to the bromide, rather than in the re-
(d)The conversion of 2-butanol to sec-butyl methanesulfonate does not involve any of the bonds to the stereogenic center, and so it must proceed with 100% retention of configuration.
An attempt to prepare this compound by the reaction gave cyclopentyl methyl ether in only 24% yield. Cyclopentene was isolated in 31% yield. (c) A2,2-dimethylpropyl halide is too sterically hindered to be a good candidate for this synthesis. The only practical method is