By providing each veterinary college with a full complement of their new synthetic canines at no cost, SynDaver will effectively eliminate the practice of terminal surgery labs. In veterinary medicine, terminal surgery labs involve teaching students how to perform certain surgeries on live, anesthetized animals, and then euthanizing the animal immediately following the procedure. The SynDaver Synthetic Canine will also eliminate the need for canine cadavers, which are also typically euthanized animals from shelters.
“We are the only company in the world that makes synthetic cadavers,” Sakezles says. “And all other anatomical models on the market are made from plastic or rubber, while ours are made from a proprietary library of more than 100 synthetic human tissues.”
The polyamine path of Neurospora crassa originates with the decarboxylation of ornithine to form putrescine (1,4-diaminobutane). Putrescine acquires one or two aminopropyl groups to form spermidine or spermine, respectively. We isolated an ornithine decarboxylase-deficient mutant and showed the mutation to be allelic with two previously isolated polyamine-requiring mutants. We here name the locus spe-1. The three spe-1 mutants form little or no polyamines and grow well on medium supplemented with putrescine, spermidine, or spermine. Cadaverine (1,5-diaminopentane), a putrescine analog, supports very slow growth of spe-1 mutants. An arginase-deficient mutant (aga) can be deprived of ornithine by growth in the presence of arginine, because arginine feedback inhibits ornithine synthesis. Like spe-1 cultures, the ornithine-deprived aga culture failed to make the normal polyamines. However, unlike spe-1 cultures, it had highly derepressed ornithine decarboxylase activity and contained cadaverine and aminopropylcadaverine (a spermidine analog), especially when lysine was added to cells. Moreover, the ornithine-deprived aga culture was capable of indefinite growth. It is likely that the continued growth is due to the presence of cadaverine and its derivatives and that ornithine decarboxylase is responsible for cadaverine synthesis from lysine. In keeping with this, an inefficient lysine decarboxylase activity (Km greater than 20 mM) was detectable in N. crassa. It varied in constant ratio with ornithine decarboxylase activity and was wholly absent in the spe-1 mutants.
factory in Tampa, Florida, mad scientists are bringing bodies to life. Not Frankensteining the dead, but using a library of polymers to craft synthetic cadavers that twitch and bleed like real suffering humans.
TAMPA, Fla. – The scientist who started , a Tampa-based company specializing in the production of synthetic cadavers for medical research, is scheduled to be on May 8.