A specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids was discovered and its importance in the development of modern pathologies is demonstrated ().
Furthermore, an immuno-dotblot assay using a suite of antibodies directed against specific cell wall epitopes showed that some RG-1 type pectins are more abundant in the mutant relative to WT plants, suggesting that ECHIDNA may function in the transport and/or recycling of cell wall compounds, the absence of which impairs cell elongation and root hair formation.
Furthermore, the observed localization patterns serve as a baseline for biochemical and mutagenic approaches toward understanding the functional roles of plant cell wall carbohydrate components in the biology of plant cells.
An expanded set of over 100 monoclonal antibodies is now available that bind to diverse carbohydrate epitopes residing on all major cell wall polysaccharides in plants, including hemicelluloses, pectins, and arabinogalactans.
The first component protein of an enzyme of fatty acid biosynthesis, fatty acidsynthase, was purified ().
Polyprenol diphosphates were shown to be involved in the biosynthesis ofpolysaccharides in () and in the biosynthesis of peptidoglycans in ().
The structure of juvenile hormone of insects was elucidated by Roller H ().
Antibodies are specific and sensitive tools to define the composition of cell walls at the cellular level and to monitor changes in those walls as a function of plant growth and development.
reported the reversed-phase separation of fatty acids by acomplex two-dimensional TLC employing a catalytic hydrogenationon the plate ().
First description of a direct titration method for analytical hydrogenation todetermine precisely the unsaturation of lipids ().
Discovery of O-amino acid (alanyl and lysyl) esters of phosphatidylglycerol in agram-positive bacteria ().
The first GLC analysis of natural triglycerides from milk fat was reported ().
Hematoside, the ganglioside of horse erythrocytes, is the first ganglioside(GM3) whose structure was elucidated ().
The complete structure of sulfatide (sulfated galactosylceramide) was elucidatedincluding the position of the sulfate group attached to the C3 of galactose ().
Methyl jasmonate was discovered in flowers of jasmine and was shown to be afragrant component in the essential oil from these flowers ().
Discovery of diether-type phospholipids in a an extremely halophilic bacteria () ().
First demonstration of the presence of 2-aminoethylphosphonic acid and itsglycerol ester in lipid extractsof the sea anemone, ().
1961, 83, 3080) made the first total synthesis of arachidonic acid.
Imai J demonstrated that the oxidative desaturation of a saturated fatty acid (palmitic acid) is depressed in diabetic rats ().
Kennedy EP described the general pathways of the glycerolipid biosynthesis in animal cells ().
Bremer J et al.
of arelationship between inositol lipids and cell proliferation (lymphocytesstimulated with phytohaemagglutinin) ().
First description of a "peptidelipid" surfactant (surfactin) composedof seven amino acids and one fatty acid (cyclic lipopeptide) produced by Marcel YL et al.
discovered the essentiality of thelong-chain polyunsaturated fatty acids (linoleic and linolenic acids) ().
Anderson RJ reported the presence of inositol in lipids of tubercle bacilli ().
First demonstration of the biosynthesis of vitamin A from
demonstrated that nearly allphosphatidylserine and a minimum of 70% of phosphatidylethanolamine is on theinside surface of the human erythrocyte membrane, thus "presenting a strongevidence for an asymmetric arrangement of phospholipids" ().
First demonstration of an inhibition of sterol biosynthesis (HMG-CoA reductaseactivity) by oxygenated derivatives of cholesterol in cultured mammalian cells ().
For the first time, the existence of polyunsaturated fatty acids was reported inmarine bacteria ().
We provide subcellular localization data for one component of the sterol biosynthesis machinery and employ cell biological approaches to demonstrate that sterol composition in meristematic cells just after cytokinesis is required for establishment of PIN2 polarity.