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Synthesis and Evaluation of Some Novel Chromone …

X-ray crystallography was used to obtain a crystal structure for the 3-aminomethylene-2,4-chromandione derivative, 46, in a bid to verify the structures of the synthesized compounds.

RESULTSDesign and Synthesis 3-Aminomethylene-2,4-chromandiones and ester chromone derivatives were synthesized by coupling several aromatic and aliphatic amines and alcohols, to chromone 3-carboxylic acid, in the presence of CDI (carbonyldiimidazole).

In conclusion, chromone derivatives were synthesized and evaluated as inhibitors of MAO.

Monomer Chem's Name Reaction List

The chromone ring system is thus a privileged scaffold for the design of inhibitors that are selective for MAO-B and has the additional advantages of generally exhibiting low mammalian toxicity and ease of synthesis.

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