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Combinatorial Biosynthesis of Anticancer Natural Products

Medical Sciences, February 2018
Curcumin (diferuloylmethane), the natural polyphenol responsible for the characteristic yellow pigment of the spice turmeric (Curcuma longa), is traditionally known for its antioxidant, anti-inflammatory, and anticarcinogenic properties. Capable of affecting the initiation, promotion, and progression of carcinogenesis through multiple mechanisms, curcumin has potential utility for both chemoprevention and chemotherapy. In human cancer cell lines, curcumin has been shown to decrease ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine biosynthesis that is frequently upregulated in cancer and other rapidly proliferating tissues. Numerous studies have demonstrated that pretreatment with curcumin can abrogate carcinogen-induced ODC activity and tumor development in rodent tumorigenesis models targeting various organs. This review summarizes the results of curcumin exposure with regard to the modulation of polyamine metabolism and discusses the potential utility of this natural compound in conjunction with the exploitation of dysregulated polyamine metabolism in chemopreventive and chemotherapeutic settings.

Los Angeles Times, January 2018
In 2011, Ferguson decided to take daily supplements of curcumin, the beneficial compound in turmeric, every night. A couple of months after she began the regimen, she started on a weekly course of hyperbaric oxygen therapy. The non-traditional treatment involves breathing in pure oxygen from an enclosed chamber with specific atmospheric pressure adjustments. Since then, Ferguson's cancer has remained stable and her blood counts are within a safe and normal range. Of course, due to the close proximity of her introduction of turmeric and the hyperbaric oxygen therapy, it's uncertain whether it was the turmeric that cured the progression of her disease. "The fact that our patient, who had advanced stage disease and was effectively salvaged while exclusively on curcumin, suggests a potential antimyeloma effect," the report concludes. "We would recommend further evaluation of curcumin in myeloma patients in the context of a clinical trial."

Shen Developments and Future Trends in Anticancer Natural Products Drug Discovery-- D.J.

Combinatorial Biosynthesis of Natural Products - …

Therefore, having more fibers through an anti cancer diet aids in overcoming these problems.

Further, proper amount of fiber assists in controlling blood sugars, triglyceride levels, lower cholesterol, and side effects of chemotherapy.
According to the National Brain Tumor Foundation, phytonutrients tend to carry immune boosting as well as anti tumor properties due to which it is necessary to include them in the anti cancer diet.

Virotherapy is a tumor-specific strategy, in whichviruses engineered to selectively kill tumor cells, throughtargeted alterations in the cancer such as p53 mutation, viraldeletion, tissue-specific transcriptional control or tumor-specificreceptors, thus, representing a promising approach for thetreatment of neoplastic diseases refractory to conventionaltherapies (,). Conditionally replicating adenoviruses(CRAds) based on the native adenoviral serotype 5 (Ad5) are mostcommonly used for generation of oncolytic agents that includeONYX-015, a vector with a deletion in the E1B region, and the AdΔ24vector, containing a 24-bp deletion in the E1A gene (–).Recent generation of oncolytic adenoviruses have combined E1A andE1B alterations in an effort to improve the selective killing ofcancer cells (). Although theirselective and antitumor activity was demonstrated in numerousexperiments with different types of tumors and, the CRAds based on Ad5 has a major limitation to besolved owing to weak expression of coxsackie adenovirus receptor(CAR) in tumor cells. This CAR deficiency makes cancer cellsresistant to Ad5 infection (). Toovercome this problem, non-replicating adenoviral vectorscontaining chimeric type 5 and type 35 or type 11 have beensuccessfully constructed, which permit CAR-independent infection oftumor cell and are used for effective gene transfer (,). Foroncolytic adenoviral vector, we and others have recently introducedAd5/35 and Ad5/3 fiber chimeric replicating viruses, anddemonstrated their broad antitumor activity regardless of CARexpression in cancer cells (–).These data obtained from the strategy of adenoviral tropismmodification using alternate cellular attachment receptors predictsan improved therapeutic index for the virotherapy of cancer.

Combinatorial biosynthesis of ‘unnatural’ natural products…

According to the National Brain Tumor Foundation, the tumor cells of brain cancer absorb at least 10 times more sugar that curbs the immune response as well as boost inflammation.
This is Low-Carb, High-Fat anti cancer diet that has the power to hinder the tumor growth in the brain, according to the Boston College biologists.
If you require further details regarding the transaction data, please contact the supplier directly.

In addition, the omega-3 fats have the power to alleviate tumor resistance due to which they are required for an effective brain cancer treatment.

Raki M, Kanerva A, Ristimaki A, et al:Combination of gemcitabine and Ad5/3-Delta24, a tropism modifiedconditionally replicating adenovirus, for the treatment of ovariancancer. Gene Ther. 12:1198–1205. 2005. : :

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Natural products as leads to anticancer drugs | SpringerLink

Combinatorial Biosynthesis of Natural Products

Daily Sabah Health, December 2017
What makes turmeric, which is quite rich in iron and manganese, a key ingredient in alternative medicine is its active ingredient curcumin. Curcumin is one of the best herbs for good health due to large amounts of vitamins C and E. Turmeric is a lightened version of curcumin that can be used in kitchens. Thanks to the curcumin in it, turmeric regulates sleep patterns. It also prevents muscles from getting tired very quickly and boosts sports performance. Some studies indicate that by using turmeric, symptoms can be decreased and inflammation-related conditions, including arthritis, can be eased. Moreover, scientists have proven that consuming turmeric helps to slow down the symptoms of Alzheimer's disease. However, the signature benefit of turmeric is in the treatment of inflammation.

Anticancer agents from natural products [electronic resource]

Raki M, Särkioja M, Desmond RA, et al:Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatmentof orthotopic ovarian cancer. Gynecol Oncol. 108:166–172. 2008. : :

Anticancer agents from natural products [electronic ..

Proceedings, December 2017
Curcumin inhibits NF-kB activation pathway at a step before inhibitor kappa B alfa (IKBα) phosphorylation. Preclinical in vivo and in vitro trials that combine curcumin with tyrosine kinase inhibitors (TKIs) have shown that this combination shows better results than each treatment alone. Retrospectively evaluated seventeen NF-kB overexpressed cancer patients were treated with i.v. and oral bioavailable formulation of curcumin and appropriate TKIs. TKIs decision was made according to genetic profiling (FoundationOne®). Toxicities and response was evaluated according to RECIST and common toxicities criteria. All patients are stage IV and heavily pretreated. Our longest experience comes from adenoid cystic carcinoma and he has treated for 72 months by oral curcumin and 8 months by i.v curcumin. Disease control rate was 89.3% (15/17) and no any grade III-IV toxicities was observed related to curcumin. Curcumin is multitargeted molecule with pleotrophic nature. Curcumin inhibits NF-κB and related proteins which promotes effectiveness of TKIs. And might be considered as long as we have to use chemotherapy, radiotherapy and TKI.

in natural product-based anticancer drug ..

Oxford University Press, December 2017
Over the past few decades, curcumin, a common food additive, has been identified as a potential anti-inflmmatory and anti-cancer compound. Curcumin is a phenolic compound extracted from the Curcuma longa plant, and was traditionally used as a spice for improving flavor and color into dishes of various Asian countries. Curcumin’s health benefits are not a new or surprising finding — the brightly colored compound has been used in Ayurvedic medicine for centuries for its potent anti-inflammatory and anti-tumor properties — but the fundamental mechanisms underlying its anti-cancer potential still remain an active area of interrogation. Intriguingly, curcumin has been shown to sensitize multiple cancers to chemotherapy drugs, and several recent studies have reported that curcumin is able to specifically target cancer stem cells. . As suggested by other groups, not only did we demonstrate that curcumin was able to enhance the sensitivity of gemcitabine in these resistant cells, we found that curcumin was also able to inhibit the growth of cancer stem cells. In our study, we also discovered that curcumin was regulating a class of non-coding RNA called “long non-coding RNAs” (lncRNAs). LncRNA is a relatively newly discovered type of non-coding RNA — RNA which does not make protein — found to be dysregulated in most cancers. We discovered that curcumin inhibits the expression of one of the most well-known lncRNA-based oncogenes, a gene that drives cancer, called PVT1. This lncRNA drives tumor progression through the regulation of another well-recognized oncogene, called EZH2. EZH2 is one of the oncogenes known to be involved in drug resistance and is identified to be a potential drug-able target. Though the generation of specific EZH2 inhibitors remains challenging, the findings from our study indicate that curcumin could be used to inhibit the expression of EZH2, as well as the non-coding RNA that regulates EZH2. Considering that curcumin is a commonly available health supplement, it presents itself as a non-toxic compound and incredibly cost-effective compound for the potential treatment of cancer patients.

combinatorial biosynthesis of natural products.

Proceedings, November 2017
Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study showed that curcumin suppresses tumor progression, and alleviates the lipid peroxidation and improves antioxidant status in the tissues of solid tumor-bearing mice.

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