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Keywords: Glycogen synthase kinase-3, GSK-3 inhibitors

23. Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. 1994;303:21-6

27. Beurel E, Mines MA, Song L, Jope RS. Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development. 2012;14:822-30

Proteins absorb light and deflect electrons in order to create an electric current.

89: 2171, 2004.) GLYCOGEN ACCUMULATION

17. Embi N, Rylatt DB, Cohen P. Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. 1980;107:519-27

9. Montori-Grau M, Tarrats N, Osorio-Conles O, Orozco A, Serrano-Marco L, Vazquez-Carrera M. . Glucose dependence of glycogen synthase activity regulation by GSK3 and MEK/ERK inhibitors and angiotensin-(1-7) action on these pathways in cultured human myotubes. 2013;25:1318-27

You'll study glycogen storage diseases later.

19. Woodgett JR, Cohen P. Multisite phosphorylation of glycogen synthase. Molecular basis for the substrate specificity of glycogen synthase kinase-3 and casein kinase-II (glycogen synthase kinase-5). 1984;788:339-47

29. Li DW, Liu ZQ, Chen W, Yao M, Li GR. Association of glycogen synthase kinase-3beta with Parkinson's disease (review). 2014;9:2043-50

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glycosaminoglycans ("mucopolysaccharides")


Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy …

6. Nikoulina SE, Ciaraldi TP, Mudaliar S, Mohideen P, Carter L, Henry RR. Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. 2000;49:263-71

How does insulin stimulate glycogen synthesis?

2. Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, Pessin JE. . The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism. 1999;274:17934-40

What is the Glycogen-Lactic Acid System

34. Lim NK, Hung LW, Pang TY, McLean CA, Liddell JR, Hilton JB. . Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain. 2014;23:4051-63

What is the Glycogen-Lactic Acid System?

GSK-3, glycogen synthase kinase-3; nM, nanomolar; ATP, adenosine triphosphate; GS, glycogen synthase; PI-3 kinase, phosphatidylinositol-4, 5-bisphosphate 3-kinase; PKB, protein kinase B; BD, bipolar disorder; AD, Alzheimer's disease; Wnt pathway, a pathway that transfers signals from the outside of the cell to the inside of the cell through cell surface receptors; β-catenin, cadherin association protein; KDa, kilodalton; IC50, the half maximal inhibitory concentration; SAR, structure activity relationship; HBD, hydrogen bond donor; HBA, hydrogen bond acceptor; PBMC, peripheral blood mononuclear cells; AIDS, acquired immunodeficiency syndrome; Pgp, P-glycoprotein; PET, positron emission tomography; MDR-MDCK assay, a permeability assay using Madin-Darby canine kidney cells with the gene; CDK1, cyclin-dependent kinase 1; ERK2, extracellular signal-regulated kinase 2, also known as mitogen activated protein kinase; IL-8, interleukin 8; ZDF, Zucker diabetic fatty; PIM1, proto-oncogene serine/threonine-protein kinase; PAK1, serine/threonine-protein kinase 1; DAPK1, death-associated protein kinase 1; MLCK, myosin light-chain kinase; FLT4, fms-related tyrosine kinase 4; CK2, casein kinase-II; CLK1, dual specificity protein kinase; PD, Parkinson's disease; HD, Huntington's disease; CNS, central nervous system; TMED, threshold minimum effective dose; TDZD, Thiadiazolidinones; PKA, protein kinase A; PKC, protein kinase C; PSP, progressive supranuclear palsy; MMSE, mini-mental status examination, cGMP, current Good Manufacturing Practice; and ITDZ, 5-imino-1, 2, 4-thiadiazole.

Glycogenolysis in muscle and liver - Tuscany Diet

36. Dewhurst S, Maggirwar SB, Schifitto G, Gendelman HE, Gelbard HA. Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS. 2007;2:93-6

Allosteric regulation of glycogenolysis in muscle and liver.

44. Denham M, Bye C, Leung J, Conley BJ, Thompson LH, Dottori M. Glycogen synthase kinase 3beta and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. 2012;30:2400-11

Answer to Define the terms glycogen, glycogenolysis, and glycolysis..

In HYPERGLYCEMIA, it is common to see glycogen "in" hepatic nuclei (really, in a deep cup-shaped depression in the side of the nucleus; the nucleus looks clear), pancreatic beta cells, and (if control is really poor) in the proximal tubular epithelial cells (why?).

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