A number of studies have been performed, which are relevant to the question of whether diazepam has any action in organophosphate poisoning other than as an anticonvulsant. These studies have concentrated on various aspects of the cholinergic system, as well as the GABAergic system and cGMP concentrations. Very large doses of diazepam (20 mg/kg), increased the acetylcholine content of mouse brain (Tonkopii et al., 1978). In the corpus striatum and hippocampus of rats exposed to sarin and soman, diazepam decreased the magnitude of the elevations in choline concentrations, but not those of acetylcholine (Flynn & Wecker, 1986). On the basis of studies on the acetylcholine synthetic system of the mouse brain, Lundgren et al. (1987) suggested that in addition to observed effects on acetylcholine turnover, diazepam might have an effect on choline transport across the blood-brain barrier. Whether diazepam-induced effects on the GABAergic system are responsible for anticonvulsant activity in soman poisoning is unresolved (Lundy et al., 1978). An effect on soman-induced elevations in central nervous cGMP concentrations has been hypothesized as a mechanism of action of the benzodiazepin
UDP-glucuronosyltransferases (UGTs) belong to a superfamily of microsomal enzymes responsible for glucuronidation of numerous endogenous and exogenous compounds including bilirubin, hormones, various drugs as well as environmental carcinogens. Glucuronidation predominantly serves as a pathway for elimination of the different glucuronidated compounds. Seventeen human UGT transcripts have been identified thus far, and the UGT proteins are differentially expressed in a wide-range of human tissues.
Principles of Synthesis and Identification (Van Nostrand Reinhold, New York, 1989).
Fenofibrate, a benzophenone derivative, has been used until recently to lower triglycerides and low-dens lipoprotein (LDL) cholesterol, thus increasing high-density.
Triphenylmethanol Bromobenzene Benzophenone Balanced Equation.
Grignard Synthesis of OF BENZENE SYNTHESIS.
This video shows you how to make benzophenone starting from benzene using the friedel crafts acylation reaction mechanism.
Johnson DD & Wilcox WC (1975) Studies on the mechanism of the protective and antidotal actions of diazepam in organophosphate poisoning. Eur J Pharmacol, 34: 127-132.