The effect of food is most obvious for the amino acids tryptophan, tyrosine, phenylalanine and these amino acids serve as the biosynthetic precursors for the neurotransmitters serotonin, dopamine, and norepinephrine.
The best-known tryptamines are , an important , and , a involved in regulatingthe sleep-wake cycle. Tryptamine found in , and are commonly used by fortheir effects. Prominent examplesinclude (from "") and (fromnumerous plant sources, e.g. , often used in brews). Many tryptamines have also been made, including the and itsrelatives. The tables below list some commonly encounteredsubstituted tryptamines.
Jump to the FAQ for an explanation.">Molecule: phenylhydrazine ("c1ccccc1NN")
One step synthesis with 4-dimethylaminobutyraldehyde acetals:
Two step synthesis with 4-chlorobutanal/dimethylamine:
Writeups of synthesis of precursors or/of dialkyltryptamines
Dimethylation of tryptamine:
Plasma and brain levels of tryptophan and the synthesis of serotonin are increased in animals and humans following a carbohydrate meal but are blocked if protein is eaten first or is included with the carbohydrates (e.g., Fernstrom, 1988; Fernstrom & Fernstrom, 1995; Spring, 1984).