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(PDF) Complete Journal PLCHB4 39(1) 111-245 (2007) ISSN 0748-6642

The rate of PCP metabolism dependedon the PCP concentration and was 1000 times lower at 1 mmol/litre (266 mg/litre) than at 0.01 mmol/litre (2.66 mg/litre).

It is cleared from the plasma by its distribution to the tissues and by excretion via the urine and the faeces; the metabolites, when produced, are also rapidly excreted.

 (PDF) Complete Journal PLCHB4 39(1) 1-110 (2007) ISSN 0748-6642

(PDF) Complete Journal PLCHB4 38(2) 77-158 (2006) ISSN 0748-6642

(PDF) Complete Journal PLCHB4 38(1) 1-76 (2006) ISSN 0748-6642

Mice exposed to technical grade PCP have shown reduced humoral immunity and an in vitro impairment of T-cell cytolytic activity (Kerkvliet et al., 1982a,b).

Cows fed technical PCP have shown thymic hypoplasia in one study (McConnell et al., 1980) but no overt differences in immunological function in another (Forsell et al., 1981).

Formulation of the Glutamate Hypothesis

Nevertheless, there is evidence that one other chlorophenol is an animal carcinogen, the lower chlorinated phenols are tumorigens, and that H6CDD found in PCP is carcinogenic, when ingested by rodents.

(PDF) Complete Journal PLCHB4 37(2) 89-161 (2006) ISSN 0748-6642

In underyearling sockeye salmon (Oncorhynchus nerka) exposed to sublethal concentrations of Na-PCP, Webb & Brett (1973) observed significant reductions in growth rate and food conversion efficiency.

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(PDF) Complete Journal PLCHB4 37(1) 1-88 (2005) ISSN 0748-6642

(PDF) Complete Journal PLCHB4 36(1) 1-88 (2004) ISSN 0748-6642

Since responses to sublethal concentrations require prolonged periods of time, the continuous-flow method is usually chosen to keep test conditions, particularly the concentration of the toxicant, constant.

(PDF) Complete Journal PLCHB4 35(2) 91-171 (2003) ISSN 0748-6642

Studies dealing with sublethal concentrations of PCP may provide more valuable information, since they involve PCP concentrations approaching ambient levels.

(PDF) Complete Journal PLCHB4 35(1) 1-90 (2003) ISSN 0748-6642

Similarly, slight differences in sensitivity were observed when Cyprinodon variegatusfry of different ages were exposed to PCP (Borthwick & Schimmel, 1978).

Effects of PCP in Normal Volunteers

Similarly, low concentrations of PCP (13.6 - 60.2 µg/litre) were used to induce physiological stress in the fresh-water fish Notopterus notopterus, as measured by the activity of hepatic acid and alkaline phosphatases and succinic dehydrogenase (Dalela et al., 1980a).

Volume 29, Number 2, 1997 PLCHB4 29(2) 123-262 (1979) ISSN 0748-6642

The toxicity of PCP for Notopterus notopterus decreased with increasing fish length up to 14.5 cm, though larger fish were again more susceptible (Gupta et al., 1982).

Volume 16, Number 2:167-72.(1984)

(Lagodon rhomboides) (1978)Pin percha 48-h marine static 96 0.038 LC50 Borthwick & (Lagodon rhomboides) pro- Schimmel (1978) larvae---------------------------------------------------------------------------------------------------------a Na-PCP.

Effects of PCP in Schizophrenic Patients

The greatest effect was observed in acid phosphatase after 30 days at a concentration of 60.2 µg PCP/litre caused a 71.09% inhibition of enzyme activity.

Glutamatergic Activity in Schizophrenia

(Cyprinodon variegatus) (1978)Sheepshead minnow 1-day- marine static 96 0.329 LC50 Borthwick & (Cyprinodon variegatus) old fry Schimmel (1978)Sheepshead minnow 14-day- marine static 96 0.392 LC50 Borthwick & (Cyprinodon variegatus) old fry Schimmel (1978)Sheepshead minnow 28-day- marine static 96 0.240 LC50 Borthwick & (Cyprinodon variegatus) old fry Schimmel (1978)Sheepshead minnow 42-day- marine static 96 0.223 LC50 Borthwick & (Cyprinodon variegatus) old fry Schimmel (1978)Pin percha adult marine flow 96 0.053 LC50 Schimmel et al.


In vivo blood variables of Notopterus notopterus (Verma et al., 1981c) were sensitive to PCP concentrations as low as 1/10th, 1/15th, and 1/20th of the 96-h LC50 of 0.083 mg PCP/litre.

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