Potter DW & Hinson JA (1987) Mechanisms of acetaminophen oxidation to N-acetyl- p-benzoquinone imine by horseradish peroxidase and cytochrome P-450.
Stewart MJ & Watson ID (1987) Analytical reviews in clinical chemistry: methods for the estimation of salicylate and paracetamol in serum, plasma and urine.
Examples off ion exchangers include naturally occurring zeolite minerals and permutit is synthetic zeolite used to soften water by exchanging sodium ions on the permutit for calcium ions from the tap water (sodium ions do not form a scum with soap).
Such treatment would have to be based on mechanisms other than inhibition of the metabolic activation of paracetamol or stimulation of glutathione synthesis.
Students have further opportunities to carry out quantitative analysis, to interpret complex data and assess the outcomes in terms of the principles of valid measurement. The topic of organic synthesis illustrates a selection of the techniques that chemists have developed to carry out reactions and purify products efficiently and safely.
In this unit the study of electrode potentials builds on the study of redox in Unit 2, including the concept of oxidation number and the use of redox half equations. Students will study further chemistry related to redox and transition metals. The organic chemistry section of this unit focuses on arenes and organic nitrogen compounds such as amines, amides, amino acids and proteins. Students are expected to use the knowledge and understanding of organic chemistry that they have gained over the whole GCE in Chemistry when covering the organic synthesis section.
This compound specifically inhibits glutathione synthesis without affecting any of the other enzyme systems pertinent to the mechanism of paracetamol toxicity (Miners et al., 1984).
Lauterberg BH, Corcoran GB, & Mitchell JR (1983) Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest, 71: 980-991.
Lauterburg BH, Corcoran GB, & Mitchell JR (1983) Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest, 71: 980-991.