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The Liver and Cholesterol Link - Lower Cholesterol …

The common causative HMs for hepatotoxicity were Ephedrae Herba and Scutellariae Radix, while CMs included antidepressants, antihistamines, and antibacterials.

Liver cleanse
Most people who talk about doing a liver cleanse probably don't know what they mean or attempting to do, and possibly may not realize that they already have a healthy, functioning liver.

Whilst the results of the studies by Broulik andTang (,) suggested that disorders of lipidmetabolism, specifically hyperlipidemia, negatively affect the bonestatus, Pharhami () demonstrated that a baseline level ofcholesterol synthesis is required for the osteoblasticdifferentiation of MSCs.

Slightly less than half of the cholesterol in the body derives from biosynthesis de novo

You make plenty of cholesterol in your liver. cholesterol-synthesis

Liver function testsA typical Liver Function Test measures several levels of enzymes and other factors.

Studies have shown that higher marrow fat content iscorrelated with lower trabecular BMD and with increased prevalenceof vertebral fracture ().Subjects with OP or osteopenia have significantly increased marrowfat content compared with that of subjects with a normal BMD. Anumber of potential mechanisms, whereby disordered lipid metabolisminteracts with bone microcirculation and the development of OP,have been proposed. Dysfunction of lipid metabolism may contributeto impaired nitric oxide and enhanced endothelin production,resulting in endothelial cell dysfunction and an increased risk ofthrombus formation (). Inaddition, high doses of corticosteroids contribute to cholesterolsynthesis, which results in fat deposition, liver steatosis and fatemboli (). Disordered lipidmetabolism increases the size of adipocytes in the medullarycavity, which results in an increase in the pressure of the marrowcavity, which in turn compromises perfusion via triggering of thecoagulation pathway (,). The average diameter of adipocytesin the BM has been shown to increase by >10 m (). Furthermore, increased levels ofcirculating lipids lead to accumulation of lipids in the BM, withsubsequent occlusion of subchondral vessels as a result of fatemboli ().

Due to the idiosyncratic nature of hepatotoxicity, monitoring of liver function tests and immediate discontinuation upon abnormal lab findings or signs and symptoms of liver dysfunction are crucial since most cases of hepatic damage are reversible when detected early.

REGULATION OF CHOLESTEROL SYNTHESIS IN THE LIVER…

*The ranges for the test results listed above are dependent on the lab, the testing done and are relative. Some specialist allow for a much larger range before they diagnose “true” Liver Disease. After receiving your test results, please consult with an internal specialist and have them explain the results to you.

To achieve the reduce cholesterol level understand the role of liver in the production cholesterol

A thorough approach is needed for a correct diagnosis of any liver problem. An organ like the liver that
is so intimately involved with other important organs will exhibit symptoms that mimic disease in these other organs. Also, what initially might appear as a diseased liver is in reality a disease elsewhere in the
body that is involved with the liver secondarily. This is why it is crucial to follow a thorough and methodical approach called the diagnostic process.

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Cholesterol: Synthesis, Metabolism, Regulation


Glossary | Linus Pauling Institute | Oregon State University

Manifestations of liver disease that are particularly important include jaundice (a yellowish discoloration of the skin and the whites of the eyes), cholestasis (reduction or stoppage of bile flow), liver enlargement, portal hypertension (abnormally high blood pressure in the veins that bring blood from the intestines to the liver), ascites (accumulation of fluid in the abdominal cavity), liver (hepatic) encephalopathy (a liver disorder in which toxins build up in the blood, leading to brain dysfunction), and liver failure.

Liver disease diagnosis
Liver function tests for elevated liver enzymes is the most important first step to be done.

Bile Acid Synthesis, Metabolism and Biological Functions

The liver plays an important role in the production of cholesterol in all animals, including humans. Even vegetarians in the strictest sense get about 800-1,500 milligrams of cholesterol a day, just produced by their liver processing saturated fats and sugars. If the liver did not produce some cholesterol, even low cholesterol levels, strict vegetarians could not survive. That is because the majority of cholesterol in food form comes from animal based foods.

The fact is our bodies need cholesterol. However, there is a difference between the cholesterol made by the body and dietary cholesterol. The cholesterol that the liver produces is vital to strengthening the membranes of each and every cell in the body. It is also important in the production of many hormones in the body including estrogen, progesterone, cortisone, and aldosterone. These steroid hormones help the body manage stress and balance sodium and water in the body, not to mention regulate sexual function. Blood cholesterol that primarily comes from diet is what doctors are most concerned about.

Culture and genes play a huge role in how much dietary cholesterol will translate into blood cholesterol. Some cultures and people can consumer high fat and high cholesterol diets without raising their blood cholesterol. This is true of one Southern African tribe of cattle herders who for thousands of years have consumed a diet that would have most modern day Americans in cardiac arrest. Yet they manage to maintain more than ideal blood cholesterol levels of 150 mg/dL. This is because their liver production of cholesterol is able to balance out the consumption of high cholesterol foods.

Not all cholesterol is bad. It is when blood cholesterol is in excess of what the body needs to perform its job with the cells and hormones that we should be concerned about having lower cholesterol. Lower cholesterol levels can be achieved by a good diet based on whole grains and vegetables with limited animal proteins. Find out how in The 60 Day Prescription Free Cholesterol Cure.

Bile Acid Synthesis and Utilization

Aspartate Aminotransferase: AST - an enzyme seen in the liver, heart, kidney, skeletal muscle and brain. The half life of the AST in the blood stream is much shorter than that of ALT, therefore the values of AST tend to drop more rapidly once liver function is resumed. AST elevations and ALT elevations should parallel each other in liver disease

The end products of cholesterol utilization are the bile acids

Gamma Glutamyltransferase: GGT – This enzyme is has its highest concentration in the kidneys and pancreas, but it is also found in the liver and other organs. The major proportion of GGT in the serum seems to come from the liver. Elevations of GGT in disease seem to stem from new synthesis rather than leakage, therefore the changes seen due to disease are not spectacular. Large elevations of GGT are more commonly associated with pancreatitis and bile duct obstruction.

The liver is the largest organ in the body

These series of organic acids circulate almost entirely in the localized blood flow between the intestines
and the liver (a.k.a. the Portal system). The flow is typically from the liver, into the bile duct system, then excretion into the intestines to aid digestion after a meal, to be re- absorbed into the portal system and recycled by the liver. Very little of the bile acids escape from the portal circulation system into the rest of the body. Leakage is considered abnormal and is a sure sign of a liver abnormality. This is one of the most sensitive tests available to diagnose liver disease. While the liver does actually manufacture this product, it has tremendous reserve capacity and can easily meet the bodies demand for bile acids despite severe disease. As a result of this reserve, the bile acid levels do not typically drop due to liver disease.

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