The selected candidate will receive comprehensive training in organic synthesis and medicinal chemistry, and will have an opportunity to interact with biologists on a regular basis.Our laboratory is quite international and has collaborations with academic and industrial partners within the Czech Republic and abroad.
2-aryl substituted benzothiazoles can be synthesized using reaction of substituted anilines with nitrobenzoyl chloride in pyridine under reflux and further treatment with Lawesson’s reagent and then cyclization of intermediate using Potassium ferricyanide 25.
Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The small and simple benzothiazole nucleus possesses numerous biological properties like - antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. These activities are also possessed by its substituted derivatives as well. The present review focuses on some commonly used easy procedures to synthesize the benzothiazole moiety and its derivatives, which comprise of different biological activities.