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mesoporous silica nanoparticles ..

AB - Mesoporous silica nanospheres (MSNs) are a promising material for magnetic resonance imaging (MRI) contrast agents. In this paper multifunctional MSNs with cleavable Gd(III) chelates are synthesized and characterized, and their applicability as MRI contrast agents is demonstrated both in vitro and in vivo. The MSNs contain Gd(III) chelates that are covalently linked via a redox-responsive disulfide moiety. The MSNs are further functionalized with polyethylene glycol (PEG) and an anisamide ligand to improve their biocompatibility and target specificity. The effectiveness of MSNs as an MRI imaging contrast agent and their targeting ability are successfully demonstrated in vitro using human colon adenocarcinoma and pancreatic cancer cells. Finally, the capability of this platform as an in vivo MRI contrast agent is tested using a 3T scanner. The Gd(III) chelate was quickly cleaved by the blood pool thiols and eliminated through the renal excretion pathway. Further tuning of the Gd(III) chelate release kinetics is needed before the MSN system can be used as target-specific MRI contrast agents in vivo.

Among inorganic-based nanomaterials, Mesoporous Silica Nanoparticles (MSNs) have several attractive properties as a drug-delivery system, such as large surface areas, tailorable pore sizes, controllable particle sizes and shapes, dual-functional surfaces (exterior and interior), ease of large scale synthesis and stability. The size- and shape-controllable pores of MSNs can store pharmaceutical drugs and prevent their premature release and degradation before reaching their designated target., Chemotherapeutic drugs can be loaded onto MSNs, replacing the need to use solvents that are often toxic for healthy tissues.,

FIG. 5: RELEASE PROFILE OF MELOXICAM AND MELOXICAM LOADED SILICA NANOPARTICLES

Mesoporous Silica Nanoparticles: Synthesis, ..

For unmodified MSNs,silicaconnectors between nanoparticles were clearly observed.

a) Scheme of synthesizing albumin-based nanoparticles with different strategies and the biomedical applications of the prepared nanoparticles. Parts of the figure adapted with permissions from [, ].

RESULTS: The formulation of mesoporous silica nanoparticles loaded with Meloxicam was developed using sol-gel method. Drug loading and surface functionalisation was confirmed by FT-IR analysis.

Mesoporous silica nanoparticles ..

Surface charge of the particle with and without the presence of PEI was determined. The presence of PEI on functionalised MSN (Batch MSMFP) effectively made the zeta potential positive. Whereas, the zeta size in the presence of PEI was observed to be higher than the uncoated particles. Silica nanoparticles represent average particle size ranging from 200 - 400 nm.

Chen, Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery,

The heart of our work in functional core-shell silica nanoparticles is the development of fluorescent particles based on organic dyes covalently incorporated into the silica matrix. Reactive dye molecules are cross-linked to a silica precursor, which is reacted to form a dye-rich core particle. This core is then encapsulated in a layer of pure silica to create the core-shell particle.

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Biocompatibility of Mesoporous Silica Nanoparticles?


Synthesis of mesoporous silica nanoparticles by sol–gel …

[1] A. Burns H. Ow, U. Wiesner, "Fluorescent core-shell silica nanoparticles: towards 'Lab on a particle' architectures for nanobiotechnology" 35, 1028-1042 (2006).

Synthesis of Mesoporous Silica Nanoparticles.

[2] J. Choi, A. Burns, R. Williams, Z. Zhou, A. Flesken-Nikitin, W. Zipfel, U. Wiesner, A. Niktin, "Core-shell silica nanoparticles as fluorescent labels for nanomedicine" 12 (6) 064007-(1-11) (2007).

Synthesis of Mesoporous Silica Nanoparticles - …

[3] H. Ow, D. Larson, M. Srivastava, B. Baird, W. Webb, U. Wiesner,"Bright and Stable Core-Shell Fluorescent Silica Nanoparticles", 5 (1), 113-117 (2005)

Synthesis of Mesoporous Silica Nanoparticles

Amorphous silica is an excellent host material for a wide variety of functional materials, including fluorescnt dyes, metal nanoparticles and biomolecules. Further, it can be tailored to create architectures unachievable in such functional materials. One of the goals of our work in silica nanoparticles is the integration of multiple functionalities to create so-called lab-on-a-particle architectures, which would be capable of specific, localized multi-parameter analyses which are not possible using current technologies.

Mesoporous silica nanoparticle based nano drug …

Mesoporous silica nanospheres (MSNs) are a promising material for magnetic resonance imaging (MRI) contrast agents. In this paper multifunctional MSNs with cleavable Gd(III) chelates are synthesized and characterized, and their applicability as MRI contrast agents is demonstrated both in vitro and in vivo. The MSNs contain Gd(III) chelates that are covalently linked via a redox-responsive disulfide moiety. The MSNs are further functionalized with polyethylene glycol (PEG) and an anisamide ligand to improve their biocompatibility and target specificity. The effectiveness of MSNs as an MRI imaging contrast agent and their targeting ability are successfully demonstrated in vitro using human colon adenocarcinoma and pancreatic cancer cells. Finally, the capability of this platform as an in vivo MRI contrast agent is tested using a 3T scanner. The Gd(III) chelate was quickly cleaved by the blood pool thiols and eliminated through the renal excretion pathway. Further tuning of the Gd(III) chelate release kinetics is needed before the MSN system can be used as target-specific MRI contrast agents in vivo.

The biomedical applications of mesoporous silica nanoparticles ..

[3] H. Ow, D. Larson, M. Srivastava, B. Baird, W. Webb, U. Wiesner,"Bright and Stable Core-Shell Fluorescent Silica Nanoparticles", 5 (1), 113-117 (2005)

Mesoporous silica Nanoparticles have been ..

Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient of human blood without immunogenicity and encouraged by its successful clinical application in Abraxane, albumin has been regarded as a promising material to produce nanoparticles for bioimaging and drug delivery. The strategies for synthesizing albumin-based nanoparticles could be generally categorized into five classes: template, nanocarrier, scaffold, stabilizer and albumin-polymer conjugate. This review introduces approaches utilizing albumin in the preparation of nanoparticles and thereby provides scientists with knowledge of goal-driven design on albumin-based nanomedicine.

Mesoporous Silica Nanoparticle Based Nano Drug …

Stem cells hold great promise for the treatment of multiple human diseases and disorders. Tracking and monitoring of stem cells after transplantation can supply important information for determining the efficacy of stem cell therapy. Magnetic resonance imaging (MRI) combined with contrast agents is believed to be the most effective and safest non-invasive technique for stem cell tracking in living bodies. Commercial superparamagnetic iron oxide nanoparticles (SPIONs) in the aid of transfection agents (TAs) have been applied to labeling stem cells. However, owing to the potential toxicity of TAs, more attentions have been paid to develop novel SPIONs with specific surface coating or functional moieties which facilitate effective cell internalization in the absence of TAs. This review aims to summarize the recent progress in the design and preparation of SPIONs as cellular MRI probes, to discuss their applications and current problems facing in stem cell labeling and tracking, and to offer perspectives and solutions for the future development of SPIONs in this field.

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