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Depression in older adults | The BMJ


Mens Health, February 2018
At the end of the study, the curcumin group experienced a 28 percent improvement in their memory tests, while those popping the placebo didn’t see a significant change. What’s more, they also saw a slight boost in their mood compared to the placebo poppers. The researchers can’t say exactly why curcumin might have these effects. But after analyzing the brain scans, they noticed that people taking curcumin had lower levels of both abnormal proteins, specifically in areas of the brain that influence memory and emotion. Plus, curcumin is an antioxidant that might fight inflammation, explains study author Gary W. Small, M.D., director of the UCLA Longevity Center. The more inflammation you have in your brain, the more likely you are to experience cognitive problems and depression, he says.


Doctor Oz, February 2018
UCLA researchers find consumption of curcumin helps mood and memory. Forty adults with mild memory complaints were randomly selected to ingest curcumin twice daily or a placebo for 18 months. They underwent cognitive assessments and PET scans to test amyloid in the brain, which is associated with negative effects on memory and emotional functions. Those taking curcumin improved their memory tests by twenty-eight percent, demonstrated mild mood improvements, and showed far smaller levels of amyloid than the placebo group. A follow-up study will explore the possibility of curcumin possessing antidepressant effects and whether it can help your genetic risk for Alzheimer’s. These findings back up the far lower rate of Alzheimer’s in India’s senior citizens, whose diet is high in curcumin.

Venturing Boldly Into Neuroscience | LifeSciVCLifeSciVC

Neuropsychiatric Disease and Treatment - Dove Press

21.09.2017 · Neuroscience has quietly become a hot space for startups


Express, January 2018
The 67-year-old, who had battled blood cancer for five years, began taking daily doses of curcumin, one of the main compounds of turmeric. More familiar as an ingredient in curries the spice is also an ancient remedy for a variety of ailments. While this natural approach won’t work for everyone the Londoner’s cancer-cell count is now negligible. As Dieneke’s doctors hail the remarkable results we take a look at turmeric and the ways in which it may boost health. The spice, recognisable by its golden colour, is ground from the dried root of a plant called Curcuma longa. A relative of ginger it thrives in warm, moist conditions and has long been used as a medicine in Chinese and Indian cultures. Turmeric’s healing powers are attributed to phytochemicals, compounds which are present in many plants. Curcumin, which is found in turmeric, is claimed to be one of the most powerful remedies in nature’s medicine cabinet. Another benefit of turmeric may be combating depression, stress and anxiety. It is claimed curcumin can be used as a natural alternative to drugs such as Prozac, working by inhibiting an enzyme in the brain that is responsible for depression. There may be a double whammy as it is claimed curcumin can also increase levels of serotonin and dopamine – chemicals that boost happiness. The powers of curcumin could even extend to improving the sex life of men by improving blood flow to the genitals.


Pop Sugar, February 2018
Research published in the journal Oncogene found that turmeric is actually a more effective anti-inflammatory than over-the-counter pain relievers like aspirin and ibuprofen. ADVERTISEMENT This is a modal window. The media could not be loaded, either because the server or network failed or because the format is not supported. Turmeric can also be used to increase levels of brain-derived neurotrophic factor (BDNF), which is a growth hormone in the brain that, when low, is responsible for increased risk of Alzheimer's disease, depression, and a host of other mental ailments. The curcumin in turmeric has also been proven to reverse symptoms of heart disease. Many other studies have found a parallel function and effect of the substance on your heart as compared to exercise.

Traumatic Brain Injury In The Aging Population


Daily Sabah Health, December 2017
What makes turmeric, which is quite rich in iron and manganese, a key ingredient in alternative medicine is its active ingredient curcumin. Curcumin is one of the best herbs for good health due to large amounts of vitamins C and E. Turmeric is a lightened version of curcumin that can be used in kitchens. Thanks to the curcumin in it, turmeric regulates sleep patterns. It also prevents muscles from getting tired very quickly and boosts sports performance. Some studies indicate that by using turmeric, symptoms can be decreased and inflammation-related conditions, including arthritis, can be eased. Moreover, scientists have proven that consuming turmeric helps to slow down the symptoms of Alzheimer's disease. However, the signature benefit of turmeric is in the treatment of inflammation.

Curcumin 95% Turmeric Extract Capsules


Huffington Post, November 2017
Curmeric is a spice and a part of the ginger family that has been used for thousands of years. It's rich in a powerful natural phenol called curcumin. This wonder herb has been shown to be effective in treating low moods, either alone or in combination with an antidepressant. Curcumin contains powerful phytochemicals that reverse inflammation, and chronic inflammation has been shown to contribute to the development of a wide variety of disorders, depression being one that may be closely linked. A 2014 randomized control study compared three groups of 20 participants each. The three groups were given curcumin alone, Prozac® + 1g of oil based curcumin, or Prozac alone for a six-week period. They then had their low moods measured on a common scale. Surprisingly, the group on curcumin alone did just as well as those on Prozac alone. While there was not a major statistical significance among any of the three groups, the group on the combination scored best. The researchers found no safety concerns with the daily curcumin usage and concluded "This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD [major depressive disorder] without concurrent suicidal ideation or other psychotic disorders.”

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Complex Regional Pain Syndrome CRPS/RSD - The …


Pharmacotherapeutic potential of ginger and its …

Finally, ventricular enlargement can occur as a result of hydrocephalus. Hydrocephalus will often occur as a result of trauma to the head and brain. Most commonly, following a brain bleed the dead blood cells circulating within the cerebral spinal fluid can clog up the fluid drains in the brain, leading to increase intracranial pressure. This increased pressure leads to expansion of the ventricles and atrophy. If your client, following trauma, slowly develops a gait disturbance, that is the most common and first sign of physical symptoms from the emergence of hydrocephalus. Cognitive problems and death can follow. The lifetime insertion of a shunt (the cure) is a serious and costly medical expense.

Depression Flashcards | Quizlet

Ventricular atrophy is also commonly seen in the elderly. An MRI will show increased fluid spaces within the brain. It has been shown that ventricular expansion occurs faster in those developing mild cognitive impairment years prior to clinical symptoms, eventually more rapid expansion occurs 24 months prior to the emergence of clinical symptoms (Carlson NE et al. 2008). What makes this difficult, for litigation purposes, is that ventricular enlargement has been noted as a common sequelae as TBI. Ventriculonegaly was found in 39% of patients with severe head injury and 27% of those with moderate head injury. Increased ventricular size was evident four weeks after injury in 57% of the patients in two months after injury in 69% of the patients. Post traumatic ventriculonegaly was significantly correlated with outcome. (Poca MA et al. 2005).

So depression is an inflammatory disease, but where …

Currently, the literature attempting to verify the rate and extent of progression of WMH over time in elderly patients and what that means to their cognition is somewhat unclear. Several studies done in Austria (Schmidt, R et al 2002, 2003, 2005) did not find an association between the evolution of WMH and a decrease in cognitive functioning. However, the same researchers in 2005 (Danderflier, WM et al 2005), found the load of WMH was independently associated with general cognitive functioning in a sample of independently living Danes. Other studies have generally confirmed the relationship between the increased load of WMH and cognitive decline, atrophy, balance problems and less ability to live independently (See Subcortical Hyperintensities Are Associated with Cognitive Decline in Patients with Mild Cognitive Impairment, Debette et al, 2007). Geriatric depression has been found to be associated with an increase load with WMH (Taylor, WD et al 2003)

in major depression: a review and hypothesis.


Science Trends, November 2017
It has been suggested that the compound curcumin helps the immune system destroy amyloid plaque, reducing the production of inflammatory cytokines. In doing so, brain function deterioration is reduced, slowing down the development of Alzheimer's disease. Epidemiological studies have looked at the neuroprotective effect of curcumin and have demonstrated that regular consumption has reduced other cognitive deficits in the elderly. Over the years curcumin has been a main focus for research regarding its strong anti-tumor effects. In fact, several preclinical trials have demonstrated curcumin to have both chemopreventive and anti-tumor effects against certain types of cancer. This naturally occurring polyphenolic compound recently has shown promise as a dietary therapy for pancreatic cancer. Of course, it shouldn't be thought of as a primary means for treating cancer, but it may reduce tumor promotion and minimize the spread of cancer. Turmeric has anti-inflammatory abilities containing more than two dozen compounds which may help relieve osteoarthritis pain. Again, it’s the compound curcumin that works as an anti-inflammatory agent. Clinical studies have found that curcumin provided protection to joint inflammation in individuals with osteoarthritis. Ulcerative colitis is a chronic, inflammatory bowel disease causing inflammation in the digestive tract. The disease tends to flare up and subside at random. Studies have shown people with ulcerative colitis who took curcumin had a significantly lower relapse rate than people who did not take curcumin. A meta-analysis showed curcumin had a high effect in reducing symptoms of depression, such as irritable mood, reduced interest in pleasurable activities, fatigue or feelings of worthlessness. The analysis suggests that curcumin could possibly have a role in treating the symptoms of major depression.

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