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Optical coherence tomography and SERS.

Dr. Bouma has extensive experience with the development and translation of novel diagnostic instrumentation for biological and medical applications. His research group at the Massachusetts General Hospital has developed and conducted the first human studies with optical coherence tomography in the gastrointestinal tract (esophagus, stomach, duodenum, colon, and biliary tree) for screening and surveillance roles in detecting early cancer. Patents from this work have resulted in commercially available gastroesophageal imaging systems.

Optical coherence tomography (OCT) provides real-time, objective, in-vivo, optical cross-sectional representations of the retina and optic nerve. Recent innovations in image acquisition, including the incorporation of Fourier/spectral-domain detection, have improved imaging speed, sensitivity and resolution. Still, there remain specific structures within ocular OCT images, such as retinal ganglion cells (RGCs), which are of clinical interest but consistently have low contrast. This makes it difficult to differentiate between surrounding layers and structures. The objectives of this project were: 1. To establish a reliable method for OCT imaging of the healthy and diseased mouse eye in order to provide a platform for testing the utility of OCT contrast agents for ocular imaging, 2. To develop antibody-conjugated gold nanoparticles suitable for targeting specific structures and enhancing OCT image contrast in the mouse eye, and 3. To examine the localized contrast-enhancing ability and biocompatibility of gold nanoparticle contrast agents in-vivo. Our organizing hypotheses were that nanoparticles could improve contrast by modulating the intensity of backscattered light detected by OCT and that they could be directed to structures of interest using antibodies specific to cellular markers.A reproducible method for imaging the mouse retina and quantifying retinal thickness was developed and this technique was then applied to a mouse model for retinal ganglion cell loss, optic nerve crush. Gold nanorods were designed specifically to augment the backscattering OCT signal at the same wavelengths of light used in current ophthalmic OCT imaging schemes (resonant wavelength Λ = 840 nm). Anti-CD90.2 (Thy1.2) antibodies were conjugated to the gold nanorods and a protocol for characterization of the success of antibody conjugation was developed. Upon injection, the gold nanorods were found to remain in the vitreous post-injection, with many consumed by an early inflammatory response and only very few reaching the internal limiting membrane and passing into the retina. Our findings suggest that, while gold nanorods are able to locally increase OCT signal intensity in the vitreous, their utility in the retina may be limited.

(2012), Optical coherence tomography

based on low-coherence optical tomography.

Comparing MachineLearning Classifier for Diagnosing Different Angle Closure Mechanisms fromAnterior Segment Optical Coherence Tomography Imaging.

Kerim Allahverdiev, Azerbaijanian by birth, was born in 1944 and educated at the Moscow Power Engineering Institute (MEI), where he received degree in Electrical Engineering in 1967. His Institute diploma thesis was performed at the Lebedev Institute of Physics, Moscow and was devoted to the superconducting properties of layered Niobium Selenide crystals. In 1967 he finished 2 years English school in Moscow. In 1972 he received the degree of the Candidate of Physical Mathematical Sciences working at the Institute of Physics Azerbaijan National Academy of Sciences in close collaboration with the Lebedev Institute of Physics. In 1974-1975 he had Postdoctoral at the Clarendon Laboratory of Oxford University, UK. In 1982 he received a degree of Doctor of the Physical Mathematical Sciences submitting the thesis to the Institute of General Physics also, Moscow, working in close collaboration with the Institute of Spectroscopy and Institute of High Pressure Physics, Troitsk, Moscow Region. Since 1985 he is Professor in Physics. In 1992-1995 he is Professor in Physics at the Middle East Technical University, Ankara, Turkey. Since 1995 he is Senior Scientific Researcher at the Marmara Research Centre (MRC) of the Turkish Scientific and Technological Council (TUBITAK), Gebze, Turkey and Senior Research Scientist at the Institute of Physics Azerabaijan National Academy of Sciences.

As a visiting professor, researcher and invited lecturer, Prof. K. Allahverdiev has presented, taught seminars and engaged in scientific collaboration at more than 40 Universities and Research Centers around the world, including Moscow State University; Oxford University, Cambridge University; Sheffield University, UK; London University; Imperial College, UK; MPI FKF, Stuttgart, Germany; RWTH Aachen, Germany; Bochum University, Germany; Bayreuth University, Germany; Hamburg University, Germany; US Air Force Wright Patterson Lab., Dayton; Colorado State University, USA; University of Cincinatti, USA; Tsukuba University, Japan and Madrid University, Spain.

He has been directing academic research in the field of physics and practical applications of layered semiconductors for over 30 years. Research Achievements include: new effective nonlinear materials in the system of layered gallium selenide- type semiconductors; first observation and explanation the nature of the low-temperature ferroelectric and high-pressure phase transitions in ternary layered chalcogenides. New class of the ferroelectric-semiconductors was discovered in a frame of joint research with the Institute of Spectroscopy (Prof. E. Vinogradov et al.), Troitsk, Moscow Region; first experimental investigation of the influence of ultra-short laser pulses on the transient-transmission change of layered A3B6 crystals and observation of quantum beats as due to the coherently excited fully symmetric phonons. As a result, new type of ultra-fast light modulator was suggested; first observation of the second harmonic generation in gallium selenide at 10.6 µm an 1579 nm and resonant excitonic second-harmonic generation; influence of intercalation on the electronic and vibration properties of gallium selenide-type crystals.

K. Allahverdiev hands-on experience in: modern spectroscopy techniques-also under pressure (pump-probe experiments, Raman scattering, nonlinear harmonic generation and wave mixing, photo- and electro- luminescence, exciton spectroscopy and others; growth and characterization of single crystals, nanocrystals and polycrystalline materials; carrier transport and galvanomagnetic measurements, dielectric spectroscopy; supervising the students at graduate and undergraduate levels, advising Ph.D Theses; demonstrated ability in project management, communication and organization skill, energetic.
Professor Allahverdiev has received several awards, honors, membership and fellowships including Azerbaijan State Prize in Science (1988); Krupp's stipendium, Technical University Aachen (1989); Window-on- Science Award, US Air Force European Office of Aerospace R&D, USA (1996, 2001); Royal Society Award as visiting Professor (1987, 1989); Citation in the USSR Academy of Sciences List of Best Achievements of the Year for the determination of the interlayer parameters and the peculiarities of the phonon spectra of A3B6 semiconductors (1978). Same Citation for different achievements in 1983, 1989 and 1991. He is a member: of New York Academy of Sciences (1998); Azerbaijan National Academy of Creation (1988); Russian Engineering Academy of Sciences, named by A. M. Prokhorov (2008); Member of the Organizing Committee of the European High Pressure Research Group (EHPRG) (1987-1990, 1991-1994, 1996-1999); Member of the Editorial Board, Turkish Journal of Physics; Reviewer of the JOSA, JAP, Materials Research Bulletin and others.

Professor Allahverdiev has published more than 275 articles on the linear and nonlinear optical properties of layered semiconductors, 1 book and 7 review articles. He has 5 patents.

Although a very busy personality Professor Allahverdiev finds time for sport (football, swimming). Among his other hobbies are gardening, walking, music (classic and modern).

Job description: We are looking for a bright, dynamic, and highly motivated individual to perform research in artificial intelligence with applications to ophthalmology. The successful candidate will develop 3D deep learning algorithms to predict structural and functional changes of the eye. We will use a longitudinal data set of 3D optical coherence tomography (OCT) images of the eye for training our algorithms. Due to data scarcity and heterogeneity of data acquisition modalities, Bayesian regularization techniques, robust uncertainty quantification and representation learning are likely to be crucial components of the methodologies developed in this project.

QLI | Quantitative Light Imaging Laboratory

Cancer diagnosis using optical method (optical coherence tomography)
Please read carefully and follow this guidelines
Essay outline
Cancer Diagnosis Using Optical Method (Optical Coherence Tomography [OCT])

Optical Coherence Tomography Phd Thesis optical coherence tomography phd ..

BM 517 Novel Applications in Biomedical Optics (3+0+0) 3 ECTS 7
(Biyomedikal Optikte Yeni Uygulamalar)
New research studies on bioimaging, confocal and multiphoton microscopy, optical coherent tomography, spectroscopic diagnostics, tissue engineering with light, laser tweezers and scissors, photodynamic therapy and biostimulation.

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Boğaziçi Üniversitesi - Biyomedikal Mühendisliği …


Explore the world of Quantum Mechanics

Optical coherence tomography (OCT) provides real-time, objective, in-vivo, optical cross-sectional representations of the retina and optic nerve. Recent innovations in image acquisition, including the incorporation of Fourier/spectral-domain detection, have improved imaging speed, sensitivity and resolution. Still, there remain specific structures within ocular OCT images, such as retinal ganglion cells (RGCs), which are of clinical interest but consistently have low contrast. This makes it difficult to differentiate between surrounding layers and structures. The objectives of this project were: 1. To establish a reliable method for OCT imaging of the healthy and diseased mouse eye in order to provide a platform for testing the utility of OCT contrast agents for ocular imaging, 2. To develop antibody-conjugated gold nanoparticles suitable for targeting specific structures and enhancing OCT image contrast in the mouse eye, and 3. To examine the localized contrast-enhancing ability and biocompatibility of gold nanoparticle contrast agents in-vivo. Our organizing hypotheses were that nanoparticles could improve contrast by modulating the intensity of backscattered light detected by OCT and that they could be directed to structures of interest using antibodies specific to cellular markers.A reproducible method for imaging the mouse retina and quantifying retinal thickness was developed and this technique was then applied to a mouse model for retinal ganglion cell loss, optic nerve crush. Gold nanorods were designed specifically to augment the backscattering OCT signal at the same wavelengths of light used in current ophthalmic OCT imaging schemes (resonant wavelength Λ = 840 nm). Anti-CD90.2 (Thy1.2) antibodies were conjugated to the gold nanorods and a protocol for characterization of the success of antibody conjugation was developed. Upon injection, the gold nanorods were found to remain in the vitreous post-injection, with many consumed by an early inflammatory response and only very few reaching the internal limiting membrane and passing into the retina. Our findings suggest that, while gold nanorods are able to locally increase OCT signal intensity in the vitreous, their utility in the retina may be limited.

About Dr. Robert L. Roseman | Gainesville, FL Eye …

BM 516 Biophotonics (3+0+0) 3 ECTS 7
(Biyofotonik)
Principles of optics and lasers in medicine, the interaction of light with biological tissues, and the applications of light in biomedicine. Electromagnetic waves and the nature of light, geometrical optics, optical instruments, physical optics, incoherent light sources, basic laser theory, optical fibers, interaction of light with biological materials; laser Doppler flowmetry, colorimetry, flame photometry, spectrophotometry, optical flow cytometry, ultraviolet and visible absorption spectroscopy, infrared spectroscopy, optical coherence tomography.

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