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SYNTHESIS OF PHOSPHOLIPIDS - SlideShare

Milgraum LZ, Witters LA, Pasternack GR andKuhajda FP: Enzymes of the fatty acid synthesis pathway are highlyexpressed in breast carcinoma. Clin Cancer Res.3:2115–2120. 1997.

Selvendiran K, Ahmed S, Dayton A, et al:HO-3867, a synthetic compound, inhibits the migration and invasionof ovarian carcinoma cells through downregulation of fatty acidsynthase and focal adhesion kinase. Mol Cancer Res. 8:1188–1197.2010. :

Phospholipid Biosynthesis - AOCS Lipid Library

Phospholipid Biosynthesis Introduction

T1 - Phospholipids chiral at phosphorus. Synthesis of chiral phosphatidylcholine and stereochemistry of phospholipase D

N2 - A total synthesis of (11E)-9-hydroxy-13-oxotridec-11-enoate ester of 2-lysophosphatidylcholine (HOT-PC) was devised to facilitate identification of this oxidized phospholipid. A lactone, 8-(3-oxo-1H,6H-2-oxinyl)octanoic acid (1), believed to be generated through an intermediate (11E)-9-hydroxy-13-oxotridec-11-enoic acid (HOT), is produced upon autoxidation of linoleic acid. A synthesis of lactone 1 methyl ester was accomplished from HOT involving a novel trans-cis isomerization that is driven to completion by cyclization to a hemiacetal. An alternative route to this carbon skeleton was also acheived that provides the lactone 1 itself.

AB - A total synthesis of (11E)-9-hydroxy-13-oxotridec-11-enoate ester of 2-lysophosphatidylcholine (HOT-PC) was devised to facilitate identification of this oxidized phospholipid. A lactone, 8-(3-oxo-1H,6H-2-oxinyl)octanoic acid (1), believed to be generated through an intermediate (11E)-9-hydroxy-13-oxotridec-11-enoic acid (HOT), is produced upon autoxidation of linoleic acid. A synthesis of lactone 1 methyl ester was accomplished from HOT involving a novel trans-cis isomerization that is driven to completion by cyclization to a hemiacetal. An alternative route to this carbon skeleton was also acheived that provides the lactone 1 itself.

Phospholipid Synthesis and Transport in Mammalian …

Versatile Membrane Nutrition
Phospholipids are vital to the human body. Even the tiniest cell in the human body contains phospholipids – and constantly needs more. While the body can produce them itself, the synthesis is a complex process requiring adequate nutritional conditions and a coordinated, smoothly functioning enzyme system.

Phospholipid synthesis and degradation Flashcards | …

A total synthesis of (11E)-9-hydroxy-13-oxotridec-11-enoate ester of 2-lysophosphatidylcholine (HOT-PC) was devised to facilitate identification of this oxidized phospholipid. A lactone, 8-(3-oxo-1H,6H-2-oxinyl)octanoic acid (1), believed to be generated through an intermediate (11E)-9-hydroxy-13-oxotridec-11-enoic acid (HOT), is produced upon autoxidation of linoleic acid. A synthesis of lactone 1 methyl ester was accomplished from HOT involving a novel trans-cis isomerization that is driven to completion by cyclization to a hemiacetal. An alternative route to this carbon skeleton was also acheived that provides the lactone 1 itself.

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Efficient Synthesis of Phospholipids from Glycidyl Phosphates


The use of natural and synthetic phospholipids as pharmaceutical ..

The effect of zinc deficiency on prostaglandin synthesis in rat testes was determined by feeding three groups of rats egg white-based semipurified diets. One group (ZD) was fed a zinc-deficient diet and two control groups were pair-fed (PF) or fed ad libitum (AL) a zinc-sufficient diet. The concentration (nanograms/gram) of the prostacyclin metabolite, 6-keto-prostaglandin-F(1α) (6-keto-PGF(1α)), in the tunica of the homogenate was significantly lower in ZD than in PF and AL groups. However, there was no difference when 6-keto-PGF(1α) concentration was expressed as nanograms/milligrams of tunica protein. Tunica PGE2 concentrations (nanograms/gram) were not significantly altered by zinc deficiency. Concentrations of prostaglandins (PGs) in testis parenchyma were slighty higher in ZD probably as a result of increased levels of the precursor, arachidonic acid (AA). There was a highly significant correlation between PGE2 and AA in parenchyma phospholipids. PG synthesis was much greater in the tunica than in the parenchyma and prostacyclin appeared to be the major PG synthesized in both the tunica and parenchyma. It was concluded that PG synthesis is altered in the testes of zinc-deficient rats probably due to changes in concentrations of protein in the tunica and AA levels in parenchyma lipids.

Synthesis of isoprenoid phospholipids - ResearchGate

N2 - The effect of zinc deficiency on prostaglandin synthesis in rat testes was determined by feeding three groups of rats egg white-based semipurified diets. One group (ZD) was fed a zinc-deficient diet and two control groups were pair-fed (PF) or fed ad libitum (AL) a zinc-sufficient diet. The concentration (nanograms/gram) of the prostacyclin metabolite, 6-keto-prostaglandin-F(1α) (6-keto-PGF(1α)), in the tunica of the homogenate was significantly lower in ZD than in PF and AL groups. However, there was no difference when 6-keto-PGF(1α) concentration was expressed as nanograms/milligrams of tunica protein. Tunica PGE2 concentrations (nanograms/gram) were not significantly altered by zinc deficiency. Concentrations of prostaglandins (PGs) in testis parenchyma were slighty higher in ZD probably as a result of increased levels of the precursor, arachidonic acid (AA). There was a highly significant correlation between PGE2 and AA in parenchyma phospholipids. PG synthesis was much greater in the tunica than in the parenchyma and prostacyclin appeared to be the major PG synthesized in both the tunica and parenchyma. It was concluded that PG synthesis is altered in the testes of zinc-deficient rats probably due to changes in concentrations of protein in the tunica and AA levels in parenchyma lipids.

(for fatty acid synthesis) 2) ..

AB - The effect of zinc deficiency on prostaglandin synthesis in rat testes was determined by feeding three groups of rats egg white-based semipurified diets. One group (ZD) was fed a zinc-deficient diet and two control groups were pair-fed (PF) or fed ad libitum (AL) a zinc-sufficient diet. The concentration (nanograms/gram) of the prostacyclin metabolite, 6-keto-prostaglandin-F(1α) (6-keto-PGF(1α)), in the tunica of the homogenate was significantly lower in ZD than in PF and AL groups. However, there was no difference when 6-keto-PGF(1α) concentration was expressed as nanograms/milligrams of tunica protein. Tunica PGE2 concentrations (nanograms/gram) were not significantly altered by zinc deficiency. Concentrations of prostaglandins (PGs) in testis parenchyma were slighty higher in ZD probably as a result of increased levels of the precursor, arachidonic acid (AA). There was a highly significant correlation between PGE2 and AA in parenchyma phospholipids. PG synthesis was much greater in the tunica than in the parenchyma and prostacyclin appeared to be the major PG synthesized in both the tunica and parenchyma. It was concluded that PG synthesis is altered in the testes of zinc-deficient rats probably due to changes in concentrations of protein in the tunica and AA levels in parenchyma lipids.

Total synthesis of oxidized phospholipids. 3. The (11E) …

Lipogenesis occurs both in liver and adipose tissuesresulting in the synthesis of fatty acids fromacetyl CoA synthesized by glycolysis (). Acetyl CoA is then carboxylatedby ACC forming malonyl CoA. Malonyl CoA and acetyl CoA are furtherprocessed by fatty acid synthase (FAS) in palmitic acid, which isthen transformed by Elvol6 into stearic acid (). SCD1 catalyzes the formation ofpalmitoleoyl-CoA and oleoyl-CoA from palmitoyl-CoA andstearoyl-CoA, respectively (),which are preferentially transformed in triglycerides for storagein adipose tissue or phospholipids for membrane formation ().

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