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Plasmalogen Synthesis - YouTube

spectrum of the acetylated synthetic (rac)-1-(n-hexadec-1′-enyloxy)glycerol as well as of the synthetic plasmalogen revealed a trans configuration of the vinyl ether linkage.

Degradation with phospholipase A (EC 3.1.1.4) of the synthetic (rac)-plasmalogen gives a 50% conversion into free fatty acid and trans-1-(n-hexadec-1′-enyloxy)glycerol-3-phosphorylcholine while the partial synthetic enantiomeric plasmalogen was converted completely by this enzyme.

T1 - Choline and phospholipid metabolism and the synthesis of acetylcholine in rat brain

An improved synthesis of plasmalogen type lipids is described

The synthesis of truncateddocosahexaenoate phpospholipids, their generation and peptide adductionchemistry have been desscribed ().
Chronic alcohol exposure has been shown to increase circulating bioactiveoxidized phosphatidylcholines ().

In this study we determined the in vivo efficacy of an alkyl glycerol (AG), namely, 1-O-octadecyl-rac-glycerol, as a therapeutic agent for defects in plasmalogen synthesis.

Highlights Plasmalogen synthesis and regulation

A partial synthesis of cis-1-(n-alk-1′-enyloxy)-2-oleoyl-glycerol-3-phosphorylcholine was developed by application of this method to cis-1-(n-alk-1′-enyloxy)-2,3-dioleoyl glycerol.

At higher concentrations (1 to 20 mM), 4-HNEinhibits DNA and protein synthesis and activates phospholipase A2 confirmingsimilar observations in tissue in response to oxidative stress.

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On the synthesis of plasmalogens


Functions and biosynthesis of plasmalogens in health …

AB - Complementation studies, using fused cell lines from patients with peroxisomal disorders, have shown correction of defective plasmalogen synthesis and phytanic acid oxidation as wll as an increase in the number of peroxisomes. At least six complementation groups have been reported. We demostrate here that complementing cell lines also acquire the ability to oxidize very long chain fatty acids (VLCFA), and that complementation groups defined with this technique are identical to those reported previously when plasmalogen synthesis was used as the criterion for complementation. This VLCFA complementation technique is of particular value in the study of patients in whom defective VLCFA is the only or major enzymatic defect, and we show complementation between cell lines from two patients each with an isolated defect in one of the peroxisomal fatty acid beta-oxidation enzymes.

Functions and biosynthesis of plasmalogens in health and ..

Thus, thromboxane synthetase generates MDA, with thromboxane A2, from prostaglandin endoperoxides during human platelet activation (Hecker M et al., J Biol Chem 1989, 264, 141).
As 4-HNE, MDA is able to form adducts with free amino acids and many more with proteins.

of knowledge with respect to the enzymatic synthesis of ..

In contrast to their hydroxyalkenal precursors, these furan derivatives lack CD36 binding activity.

The alk-1-enyl-acyl derivatives (1-alk-1'-enyl-, 2-acyl-sn-glycero-3-phosphorylcholine) are also named choline plasmalogen (or plasmenylcholine).

On the synthesis of plasmalogens - Universiteit Utrecht

N2 - Complementation studies, using fused cell lines from patients with peroxisomal disorders, have shown correction of defective plasmalogen synthesis and phytanic acid oxidation as wll as an increase in the number of peroxisomes. At least six complementation groups have been reported. We demostrate here that complementing cell lines also acquire the ability to oxidize very long chain fatty acids (VLCFA), and that complementation groups defined with this technique are identical to those reported previously when plasmalogen synthesis was used as the criterion for complementation. This VLCFA complementation technique is of particular value in the study of patients in whom defective VLCFA is the only or major enzymatic defect, and we show complementation between cell lines from two patients each with an isolated defect in one of the peroxisomal fatty acid beta-oxidation enzymes.

Plasmalogen synthesis essay | Թեժ Լեռ Հանգստյան տուն

It was reported that thrombin treatment of endothelial cells activates a selective hydrolysis (phospholipase A2) of choline plasmalogen containing arachidonic acid in the sn2 position (85% of this phospholipid contain arachidonate) , thus releasing a lysoplasmenylcholine and a fatty acid leading to eicosanoid production (). Similar observations were made in thrombin-stimulated platelets ().

We also examined plasmalogen synthesis in ..

Complementation studies, using fused cell lines from patients with peroxisomal disorders, have shown correction of defective plasmalogen synthesis and phytanic acid oxidation as wll as an increase in the number of peroxisomes. At least six complementation groups have been reported. We demostrate here that complementing cell lines also acquire the ability to oxidize very long chain fatty acids (VLCFA), and that complementation groups defined with this technique are identical to those reported previously when plasmalogen synthesis was used as the criterion for complementation. This VLCFA complementation technique is of particular value in the study of patients in whom defective VLCFA is the only or major enzymatic defect, and we show complementation between cell lines from two patients each with an isolated defect in one of the peroxisomal fatty acid beta-oxidation enzymes.

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