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De novo biosynthesis of pyrimidine ..

Overview of the pathways for the biosynthesis of purine and pyrimidine nucleotides (THF, tetrahydrofolate). Ribonucleoside triphosphates are blue; deoxyribonucleoside triphosphates are green. To emphasise that it is not a building block for deoxyribonucleic acid (DNA) synthesis dUTP is red. Both pathways start from a common set of precursor amino acids and other metabolites. Each arrow represents an enzymatic reaction.

An S, Kumar R, Sheets ED and Benkovic SJ (2008) Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science 320: 103–106.

Purine & Pyrimidine Synthesis (de-novo) | easybiologyclass

Biochemistry - Teaching Case - De Novo Nucleotide Synthesis.

Christopherson RI and Lyons SD (1990) Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents. Medicinal Research Reviews 10: 505–548.

Jones ME (1980) Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis. Annual Review of Biochemistry 49: 253–279.

Purine Bases Can Be Synthesized de Novo or Recycled …

Zhao H, French JB, Fang Y and Benkovic SJ (2013). The purinosome, a multi‐protein complex involved in the de novo biosynthesis of purines in humans. Chemical Communications 49: 4444–4452.

Nucleosides are composed of a heterocyclic ring (defined as the base) that is attached to a ribose. Addition of a phosphate to a nucleoside, at carbon 5 of the ribose, produces a nucleotide. Nucleotides function as ubiquitous building blocks for the synthesis of all nucleic acids, and also function in enzymatic reactions as cofactors and as a source of energy. These central metabolic roles require their continued biosynthesis from readily available precursors, and this process is defined as nucleotide synthesis. The synthesis of purines starts with ribose‐phosphate, to which are attached the individual atoms of the heterocyclic base in a stepwise fashion. Pyrimidine synthesis starts with the stepwise formation of the base, to which is then added the ribose‐phosphate. Bases and nucleosides may also be recycled in salvage pathways.

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Pyrimidine metabolism - Wikipedia


Purine and Pyrimidine Metabolism - EHSL

Zrenner R, Stitt M, Sonnewald U and Boldt R (2006) Pyrimidine and purine biosynthesis and degradation in plants. Annual Reviews of Plant Biology 57: 805–836.

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