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Cholesterol: Synthesis, Metabolism, Regulation

The synthesis of cholesterol is a process that involves over 30 different steps. Which step is the r Show more The synthesis of cholesterol is a process that involves over 30 different steps. Which step is the rate-determining step of cholesterol synthesis? 1)The conversion of mevalonic acid to isopentenyl pyrophosphate 2)The conversion of squalene into squalene 2,3-epoxide by squalene monooxygenase. 3)The condensation of two acetyl-CoA molecules to acetoacetyl-CoA by thiolase. 4)The conversion of HMG-CoA to mevalonate by HMG-CoA reductase.

Anyways, blood-pressure “skeptic” or BMI “skeptic” could maintain that we all wrong about relevance of these biomarkers since old people who have low blood pressure and low BMI have higher mortality as oppose to people with higher blood pressure and higher BMI. Besides, senile devitalization causes metabolic changes in the intestine resulting in lower synthesis and absorption of cholesterol and eventually leading to plummeting blood cholesterol levels. What matters is, at what point in life we use cholesterol to predict future events. If we use people in their midlife prior to senile devitalization and drug therapies, it looks like this:

Answer to The synthesis of cholesterol is a process that involves over 30 different steps

What is the rate limiting step of cholesterol synthesis.

The reaction catalyzed by HMGR is the rate limiting step of cholesterol biosynthesis, ..

Recent years have seen the emergence of cholesterol-reducing spreads into the market. It’s often assumed that cholesterol reduction is beneficial to heart health. However, several cholesterol-modifying drugs have not been found to deliver on their promise, and some have been found to actually harm heart health. Plus, overall, taking dietary steps to reduce cholesterol has not been found to have broad benefits for health.

FOUR STAGES OF CHOLESTEROL SYNTHESIS

What is the rate determining step in cholesterol synthesis?

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could be involved in the rate-determining step of cholesterol ..


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