Studies on both young and elderly subjects using selective and non-selective COX inhibitors alike showed no differences in protein synthesis (4, 11, 15).If these findings aren't confusing enough, consider that several recent studies have investigated the long-term effects of NSAID administration on muscle growth in humans.
Acute studies on anabolic processes in humans don't necessarily correlate with long-term hypertrophy.Just because protein synthesis or signaling factors are elevated post-workout doesn't mean they'll translate into greater gains in muscle mass over a period of weeks and months (1).Another potential issue with the current body of research is that all studies to date have been carried out on untrained subjects.
and and and and and and and and and (2014)A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans. AJP: Endocrinology and Metabolism, 306 (5). E571-E579. ISSN 1522-1555