Among activators, a variety of endogenously present lipids were described ().
An antiphosphatidylcholine antibody was described in the serum of a patient diagnosed with hemolytic anemia ().
Phosphatidylserine was shown to be recognized by specific antibodies in patients with lupus anticoagulant ().
The "Nod factors" produced in legumes by as a class of signalling molecules was identified as lipo-chitooligosaccharides ().
First demonstration of phosphatidylinositol anchor on the lipopolysaccharides of a prokaryotic species, ( ).
Demonstration of the induction of the synthesis of proteinase inhibitors by methyl jasmonate in a wounded plant but also in nearby plants through the atmosphere ().
First clear demonstration that fatty acids are as unfavorable as saturated fatty acids in raising LDL cholesterol and lowering HDL cholesterol levels ().
of fatty acid ethyl ester synthesis in liver of mice treated with ethanol inhalation ().
First literature use of the term biodiesel in a Chinese paper by Wang R et al.
The first component protein of an enzyme of fatty acid biosynthesis, fatty acidsynthase, was purified ().
Polyprenol diphosphates were shown to be involved in the biosynthesis ofpolysaccharides in () and in the biosynthesis of peptidoglycans in ().
The structure of juvenile hormone of insects was elucidated by Roller H ().
demonstrated that nearly allphosphatidylserine and a minimum of 70% of phosphatidylethanolamine is on theinside surface of the human erythrocyte membrane, thus "presenting a strongevidence for an asymmetric arrangement of phospholipids" ().
First demonstration of an inhibition of sterol biosynthesis (HMG-CoA reductaseactivity) by oxygenated derivatives of cholesterol in cultured mammalian cells ().
For the first time, the existence of polyunsaturated fatty acids was reported inmarine bacteria ().
1961, 83, 3080) made the first total synthesis of arachidonic acid.
Imai J demonstrated that the oxidative desaturation of a saturated fatty acid (palmitic acid) is depressed in diabetic rats ().
Kennedy EP described the general pathways of the glycerolipid biosynthesis in animal cells ().
Bremer J et al.
described for the first time the synthesis of mixed acidtriglycerides ().
Description of the specific presence of fatty acids in the depot fats ofruminants in contrast to their absence in non-ruminants ().
The "phospholipid effect" discovered in 1953 is now attributed to aphosphoinositide in connection with phosphatidic acid metabolism(phosphatidylinositol cycle) ().
Barber JM et al.
described the first synthesis of linoleic acid () and linolenic acid ().
Reiser R demonstrated that the high levels of saturated fatty acids in ruminantanimal fat are due to the hydrogenation of the dietary unsaturated fatty acidsin the rumen ().
Asselineau J elucidated the structure of mycolic acids (
of the right structures of linoleic and arachidonic acids ().
Dam H and Doisy EA received the Nobel prize in Physiology or Medicine for the discovery of vitamin K, its pure preparation, the determination of its chemical structure and the synthetic production of that vitamin.
Cramer DL et al.
described the mechanism of the regulation of lipogenesis by fatty acids in measuring the rate of synthesis of fatty acid synthase in mouse liver ().
Holman RT et al.
of the antioxidant properties of tocopherols ().
First synthesis of linoleic acid ()
Kurz H used ethyl alcohol to derivatize fatty acids (FA ethyl esters) beforetheir analysis ().
First data on cholesterol and fatty acid metabolism after using an isotope of hydrogen(deuterium) in mice and chicks ().
Using deuterated acetate, Sonderhoff R et al. have shown that it serves asa precursor for sterols including ergosterol in yeast ().
Paul Karrer received the
discovered the essentiality of thelong-chain polyunsaturated fatty acids (linoleic and linolenic acids) ().
Anderson RJ reported the presence of inositol in lipids of tubercle bacilli ().
First demonstration of the biosynthesis of vitamin A from
A specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids was discovered and its importance in the development of modern pathologies is demonstrated ().