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Superparamagnetic maghemite nanoparticles from …

We describe the synthesis and characterization of high-performance, superparamagnetic, iron oxide nanoparticle-based, heavy metal sorbents, which demonstrate excellent affinity for the separation of heavy metals in contaminated water systems (i.e., spiked Columbia River water). The magnetic nanoparticle sorbents were prepared from an easy-to-synthesize iron oxide precursor, followed by a simple, one-step ligand exchange reaction to introduce an affinity ligand to the nanoparticle surface that is specific to a heavy metal or class of heavy metal contaminants. The engineered magnetic nanoparticle sorbents have inherently high active surface areas, allowing for increased binding capacities. To demonstrate the performance of the nanoparticle sorbents, river water was spiked with specific metals and exposed to low concentrations of the functionalized nanoparticles. In almost all cases, the nanoparticles were found to be superior to commercially available sorbent materials as well as the unfunctionalized iron oxide nanoparticles.

N2 - We describe the synthesis and characterization of high-performance, superparamagnetic, iron oxide nanoparticle-based, heavy metal sorbents, which demonstrate excellent affinity for the separation of heavy metals in contaminated water systems (i.e., spiked Columbia River water). The magnetic nanoparticle sorbents were prepared from an easy-to-synthesize iron oxide precursor, followed by a simple, one-step ligand exchange reaction to introduce an affinity ligand to the nanoparticle surface that is specific to a heavy metal or class of heavy metal contaminants. The engineered magnetic nanoparticle sorbents have inherently high active surface areas, allowing for increased binding capacities. To demonstrate the performance of the nanoparticle sorbents, river water was spiked with specific metals and exposed to low concentrations of the functionalized nanoparticles. In almost all cases, the nanoparticles were found to be superior to commercially available sorbent materials as well as the unfunctionalized iron oxide nanoparticles.

Read "Simple and facile synthesis of amino functionalized hollow ..

Surface functionalization of silica-coated magnetic ..

Synthesis, characterization, and in vitro biological evaluation of highly stable diversely functionalized superparamagnetic iron oxide nanoparticles

AB - We describe the synthesis and characterization of high-performance, superparamagnetic, iron oxide nanoparticle-based, heavy metal sorbents, which demonstrate excellent affinity for the separation of heavy metals in contaminated water systems (i.e., spiked Columbia River water). The magnetic nanoparticle sorbents were prepared from an easy-to-synthesize iron oxide precursor, followed by a simple, one-step ligand exchange reaction to introduce an affinity ligand to the nanoparticle surface that is specific to a heavy metal or class of heavy metal contaminants. The engineered magnetic nanoparticle sorbents have inherently high active surface areas, allowing for increased binding capacities. To demonstrate the performance of the nanoparticle sorbents, river water was spiked with specific metals and exposed to low concentrations of the functionalized nanoparticles. In almost all cases, the nanoparticles were found to be superior to commercially available sorbent materials as well as the unfunctionalized iron oxide nanoparticles.

In this article, we report the design and synthesis of a series of well-dispersed superparamagnetic iron oxide nanoparticles (SPIONs) using chitosan as a surface modifying agent to develop a potential T 2 contrast probe for magnetic resonance imaging (MRI). The amine, carboxyl, hydroxyl, and thiol functionalities were introduced on chitosan-coated magnetic probe via simple reactions with small reactive organic molecules to afford a series of biofunctionalized nanoparticles. Physico-chemical characterizations of these functionalized nanoparticles were performed by TEM, XRD, DLS, FTIR, and VSM. The colloidal stability of these functionalized iron oxide nanoparticles was investigated in presence of phosphate buffer saline, high salt concentrations and different cell media for 1 week. MRI analysis of human cervical carcinoma (HeLa) cell lines treated with nanoparticles elucidated that the amine-functionalized nanoparticles exhibited higher amount of signal darkening and lower T 2 relaxation in comparison to the others. The cellular internalization efficacy of these functionalized SPIONs was also investigated with HeLa cancer cell line by magnetically activated cell sorting (MACS) and fluorescence microscopy and results established selectively higher internalization efficacy of amine-functionalized nanoparticles to cancer cells. These positive attributes demonstrated that these nanoconjugates can be used as a promising platform for further in vitro and in vivo biological evaluations.

functionalized superparamagnetic ..

Most recently a research group from Singapore [] reported synthesis of chitosan-functionalized GO (GO-CS) sheets and their application for drug/gene delivery. This work shows that GO-CS sheets have a high drug payload, and the CPT-loaded GO-CS exhibits better cancer cell killing ability than the pure CPT. At the same time, GO-CS could condense plasmd DNA into stable nanoparticles, which show reasonable DNA transfection efficiency in HeLa cells at certain nitrogen/phosphate ratio. Further work on simultaneous loading and delivery of chemical drug and gene by the GO-CS nanocarrier for combined chemo- and gene- therapy is highly desired, to gain an enhanced therapeutic efficacy.

Simple Microwave-Assisted Synthesis of Functionalized N-Substituted Quinazolinones Young Scientist Journal

Valero demonstrated the synthesis of carbohydrate-coated SPIONs as MRI nanoprobes []. They showed the pH-driven assembly-disassembly natural process that occurred in apoferritin and found it effective for encapsulating maghemite SPIONs of 4 and 6 nm. The SPIONs were further functionalized with two carbohydrates, -acetyl-D-glucosamine and D-mannose vinyl sulfone derivatives. The representative mouse brain images acquired before and 120 s after administration of contrast agents and corresponding regional cerebral blood volume maps (rCBV) maps are shown in Figure . Similar to Endorem, post-contrast images and rCBV maps obtained with Apomaghemite samples depicted very well the space arrangement of cerebral vessels. This study confirmed that Apomaghemite SPIONs could serve as promising contrast agents. Furthermore, the carbohydrate-functionalized Apomaghemite NPs retained their recognition abilities, as demonstrated by the strong affinity with their corresponding carbohydrate-binding lectins.

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Surface modification, functionalization and …


Publications - University of Illinois at Urbana–Champaign

The research on superparamagnetic iron oxide nanoparticles (SPIONs) has been growing exponentially over the last several years. The field continues to drive in the direction of biomedical applications, especially molecular therapeutics by exploiting the immense qualities of SPIONs []. This includes the distinctive controllable properties such as size, shape, magnetism, crystallinity and flexibility in fabricating multifunctional SPIONs with fluorescence, targeting ligands, drugs etc, thanks to the advancements in the syntheses and functionalization techniques developed hitherto. There are some excellent synthetic methods in prior arts on the formation of superparamagnetic magnetite (Fe3O4) and maghemite (γ-Fe2O3) SPIONs, with size control, narrow distribution, water solubility and surface functionalization [-]. The co-precipitation method is a conventional synthetic paradigm where Fe(II) and Fe(III) salts are co-precipitated in a basic solution in the presence of coating materials such as polymer or dextran (or its derivatives). Although the resulted iron oxide nanoparticles (NPs) are larger in size (ca. 100 nm) and partially crystalline, the particles are readily water soluble where their surfaces are directly functionalized. Alternatively, thermal decomposition method using precursors such as Fe(CO)5, Fe(Stearate)2, with high boiling solvents (octadecene, benzyl ether) and surfactants/ligands (oleic acid, oleylamine) can be used to synthesize smaller sized hydrophobic SPIONs (5-10 nm). In order to impart the SPIONs with water solubility for biomedical applications, water-oil microemulsion method can be employed as a reaction medium for coating a hydrophilic ligand (e.g. silica, peptides) on the hydrophobic surface.

319 | Peiwen Wu, Yang Yu, Claire E

, , , , , , and (2012) Synthesis and characterisation of carbon nanotubes covalently functionalized with amphiphilic polymer coated superparamagnetic nanoparticles. Journal of Colloid and Interface Science, 383. pp. 110-117. ISSN 1095-7103

International Journal of Nanomedicine - Dove Press

T1 - Simple synthesis of functionalized superparamagnetic magnetite/silica core/shell nanoparticles and their application as magnetically separable high-performance biocatalysts

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