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hormone and StAR protein in the regulation of ..

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In eukaryotic cells, there are a lot of regulatory mechanisms, which control quality of mRNA in various steps from processing of precursor mRNA (pre-mRNA) in nucleus to translation into protein through cytoplasmic ribosome. Among these processes, RBPs play a primary role in regulating the behavior of the functionally related genes by forming the ribonucleoprotein (RNP) clusters.

Manna, P R, J Kero, M Tena-Sempere, P Pakarinen, D M Stocco, and I T Huhtaniemi. 2001. “Assessment of Mechanisms of Thyroid Hormone Action in Mouse Leydig Cells: Regulation of the Steroidogenic Acute Regulatory Protein, Steroidogenesis, and Luteinizing Hormone Receptor Function.” Endocrinology 142 (1) (January): 319–31. doi:10.1210/endo.142.1.7900.

Interaction of thyroid hormone and steroidogenic acute regulatory (StAR) protein in ..

Steroid Hormones - The Medical Biochemistry Page

Role of AMP-Activated Protein Kinase on Steroid Hormone Biosynthesis in Adrenal NCI-H295R Cells. Andrea Hirsch,

StAR is required for cholesterol shuttling across the mitochondrial membrane and appears to regulate acute steroid production (Clark and Stocco, 1997). Transcriptional or translational inhibition of StAR expression results in a dramatic decrease in steroid biosynthesis, whereas ~10–15% of steroid synthesis appears to be mediated through StAR-independent mechanisms (Manna et al. 2001) (Clark and Stocco, 1997).In contrast, chronically regulated steroid production appears to be largely mediated by increased transcription of steroidogenic enzymes (Hum and Miller 1993).

Steroidogenic acute regulatory protein (StAR) functions as a cholesterol transfer protein and acts directly on lipids of the outer mitochondrial membrane to promote cholesterol translocation (Stocco 2001). Reduction of the protein impacts on the amount of substrate available for steroidogenesis.

Peptide Hormones - The Medical Biochemistry Page

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