A business can not be everything to everyone and more than likely this customer is not alone in what they like.
Modeling all parts of the business after the image: This includes everything from business cards to the stores layout
No Clear Path
There are no set paths but being well planned is the best choice
Success is never guarenteed
Only thing to fear
Is fear itself.
Keep looking ahead
Always keep looking foward, and never get stuck in the past.
The Mentor for my project
Based on Jim Harvey's speech structures
The Nussumbam Center
A well planned business is always better off in the long run
Some important sentiments to be remembered.
For your time!
"There is heat in freezing...be a testament!" Tanya, really seemed this whole writing just flowed freely from the synthesis of your heart and mind, as if just said and complete with no editing! Excellent and so appreciated! Great collaboration too in music and film antimation, all!
But add in an intense training session with the right nutrient intake at the right time and things change; protein synthesis is activated and degradation is suppressed. The result is an accumulation of muscle protein over time, as shown in the figure below.
To understand protein synthesis, it's important to become better acquainted with mTor. Research tells us that when you force a muscle to contract against a heavy load, the primary response is an activation of protein synthesis. Protein synthesis activation is, in turn, controlled by a series of phosphorylation events orchestrated by a protein called mammalian target of rapamycin, or mTOR for short.
mTOR is arguably the most important cell signaling complex for muscle growth. It's the master-controller of protein synthesis in the cell, and there's a direct relationship between muscle growth and mTOR activation; the more a workout activates mTOR, the more the protein synthesis machinery cranks out new proteins for muscle growth and repair.
Although some studies looking specifically at resistance exercise-induced protein synthesis have shown that the addition of carbs to amino acids doesn't result in an additive effect on protein synthesis when ample amounts of amino acids are ingested, you have to look closely at the experimental model when applying research to the real world.
It's well established that the mechanical stress from training and leucine/EAAs synergistically amplify protein synthesis. Likewise, insulin may contribute to the overall burst in protein synthesis by turning on mTOR through the PI3K/akt pathway.
That doesn't mean we should discount carbs as far as protein synthesis goes; they increase insulin levels, which may still be important. Muscles are primed for increased protein synthesis for 24+ hours after training, but the acute burst in protein synthesis that occurs as a result of training or amino acid intake only lasts for a few hours.
Studies have found that both local hyperinsulinemia and the ingestion of carbs inhibits protein breakdown, with little to no effect on protein synthesis. When this was looked at specifically in the post-workout period, it was found that .
More recent studies looking at a more general model for protein synthesis show that insulin + amino acids can have a synergistically positive effect on protein synthesis, causing the greatest mTOR activation together!
Although insulin signaling may not be needed for that burst in protein synthesis that occurs in the hours after a workout, there's more to the story.
This originally came as quite a surprise, because insulin is a potent activator of protein synthesis. Insulin activates mTOR by way of PI3K/akt signaling, which is parallel to the pathways used by amino acids and mechanical stress to activate mTOR.
It's been shown conclusively in the literature that insulin signaling isn't needed to turn on training-induced protein synthesis – just leucine is required, which suggests that carbs aren't important.
Taking all this work together, it's safe to say that while insulin doesn't appear to increase exercise-induced protein synthesis, it may act to "hold the throttle open longer" for the protein synthetic machinery after a workout.
It's important to realize that the kind of intense, balls-out training most T NATION readers do probably activates protein synthesis to a greater degree than what researchers are using in the lab. Therefore, .