Over the years, we have placed much effort into the development and evaluation of novel polymer based molecular recognition systems, with the long-end goal to incorporate these as functional components in sensor, nanoscale fabrication and purification applications. Whereas previous efforts have largely been limited to synthetic polymers, we are now aiming to expand our concept to biopolymer systems. At the moment, however, activity within BPL in this area is low.
We are currently pursuing a study aiming to map the occurrence of these peptide toxins in the ribbon worms. This work involves parallel efforts, where molecular biology techniques are combined with proteomic approaches (LC-MS, MS/MS, enzymatic digestion, derivatization) to identify and sequence peptides of similar constitution to these peptides or to known toxins. New peptide toxins are synthesied in vitro, followed by structure evaluation, activity assessment and mechanistic studies. BPL is heavily involved in peptide synthesis, purification and activity evaluation.
In the Bioactive Polymers Laboratory research group, we are interested in various aspects of bioactive polymers – peptide discovery, synthesis, structures, activities and mechanisms of action, as well as development of applications.