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Recent Advances in the Synthesis of Well-Defined Glycopolymers.

To explore whether polylactosamine was associatedwith 5-FU resistance, AZT was used. AZT is a thymidine analoguethat is able to inhibit the synthesis of polylactosamine (). SW620/5-FU and its parent cellsshowed similar sensitivity to AZT (Sigma). From both cell lines>90% of cells were killed by treatment with 120 μM of AZT,whereas 80% of cells survived at 20 μM AZT (data not shown).Therefore, we applied 5 μM AZT, at which concentration nocytotoxicity was observed. As shown in , AZT treatment resulted indecreased polylactosamine in SW620/5-FU cells as determined by flowcytometry and lectin blot analysis. Then SW620/5-FU cells werepre-treated with AZT for 24 h before exposed to variousconcentrations of 5-FU for 48 h. MTT assay showed thatpre-treatment with AZT reduced the IC50 value against 5-FU of theresistant cells (72 vs. 128 μg/ml) (). These results further confirmedthat the inhibition of polylactosamine was able to reverse 5-FUresistance.

β3Gn-T1, -T2, -T3, -T4, -T7, and -T8 have been shownto possess the ability to synthesize polylactosamine chains(). To identify and evaluatecandidate genes involved in polylactosamine synthesis in SW620/5-FUcells, quantitative RT-PCR analysis was performed. We foundβ3Gn-T1, -T2, -T3, -T4, -T7, and -T8 were both highly expressed inSW620/5-FU cells(P). However, the change of β3GnT8 mRNA expression was moreobvious than other β3GnTs (i.e., >4-fold higher). These dataindicated that overexpression of β3GnT8 may be responsible for theincreased levels of polylactosamine chains in SW620/5-FU cells.

T1 - Synthesis and anti-HIV activity of a new hexopyranoside analogue of AZT

Synthesis of Functionalized Bisphosphonates via Click Chemistry.

Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates.

One-Pot Synthesis of 1,2,3-Triazoles from Benzyl and Alkyl Halides, Sodium Azide and Alkynes in Water under Transition-Metal-Catalyst Free Reaction Conditions.

Preparation, Characterization, and Application of Poly(vinyl alcohol)-graft-Poly(ethylene glycol) Resins: Novel Polymer Matrices for Solid-Phase Synthesis.

Synthesis and Versatile Reactions of β-Azidotetraarylporphyrins.

Combination of Ring-Opening Polymerization and "Click" Chemistry for the Synthesis of an Amphiphilic Tadpole-Shaped Poly(ε-Caprolactone) Grafted by PEO.

Sonication-Assisted Library Synthesis of Oxazolidinone-Carbohydrate Conjugates.

R.; Lober, S.; Hubner, H.; Gmeiner, P., Click chemistry on solid phase: parallel synthesis of -benzyltriazole carboxamides as super-potent G-protein coupled receptor ligands.

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Synthesis of New Substituted Lactones by "Click" Chemistry.

Synthesis of a Benzolactone Collection using Click Chemistry.

R., Activity-Based Protein Profiling Reagents for Protein Arginine Deaminase 4 (PAD4): Synthesis and in vitro Evaluation of a Fluorescently Labeled Probe.

Modular Synthesis of ABC Type Block Copolymers by "Click" Chemistry.

L.; Struthers, H.; Brans, L.; Anguelov, T.; Schweinsberg, C.; Maes, V.; Tourwe, D.; Schibli, R., "Click to Chelate": Synthesis and Installation of Metal Chelates into Biomolecules in a Single Step.

Synthesis of Triazole-Linked Pseudo-Starch Fragments.

B., Synthesis of azide-alkyne fragments for click' chemical applications; formation of oligomers from orthogonally protected trialkylsilyl-propargyl azides and propargyl alcohols.

Synthesis of Cyclo-PMMA via Click Chemistry Combined with ATRP.

Synthesis of Enantiomerically Pure α-[4-(1-Substituted)-1,2,3-triazol-4-yl]-benzylacetamides via Microwave-Assisted Click Chemistry: Towards New Potential Antimicrobial Agents.

Synthesis of Lanthanide(III) Chelates by Using 'Click' Chemistry.

S.; Kajiki, R.; Hanatani, H.; Kong, X.; Ozoe, F.; Matsui, Y.; Matsumura, F.; Ozoe, Y., Synthesis and Structure-Activity Relationships of 1-Phenyl-1-1,2,3-triazoles as Selective Insect GABA Receptor Antagonists.

Synthesis of Ferrocene-containing Polyacetylenes by Click Chemistry.

Synthesis and Supramolecular Structures of N3P3(N(Me)N=CHC6F5)6, -N3P3(C12H8O2)(N(Me)N=CHC6F5)4, and -N3P3(C12H8O2)2(N(Me)N=CHC6F5)2.

Design and Synthesis of Triazole-Based Peptide Dendrimers.

Synthesis of Azide/Alkyne-Terminal Polymers and Application for Surface Functionalisation through a [2 + 3] Huisgen Cycloaddition Process, "Click Chemistry".

ConCept: de Novo Design of Synthetic Receptors for Targeted Ligands.

M., Regioselective synthesis of [1,2,3]-triazoles catalyzed by Cu(I) generated in situ from Cu(0) nanosize activated powder and amine hydrochloride salts.

Click Synthesis of Fluorine-Rich Cyclotriphosphazene Hydrazones.

Synthesis of DOTA-Conjugated Multivalent Cyclic-RGD Peptide Dendrimers via 1,3-Dipolar Cycloaddition and their Biological Evaluation: Implications for Tumor Targeting and Tumor Imaging Purposes.

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