This research, involved a series of some new compounds containing different heterocyclic atoms, through synthesis of 2-mercaptobenzoxazole (2-MBO) (A) by using homemade Auto clave. The synthesis involved treatment of 2-MBO with 2-Chloroacetyl chloride to give 2-Chloroacetyl thio benzoxazole (A1), the product was treated with hydrazine hydrate to give 2-(aceto hydrazide) thio benzoxazole (A2). Synthesis of 2-(aceto phenyl semi carbazide) thio benzoxazole (A3) yielded from reaction of 2-(aceto hydrazide) thio benzoxazole (A2) with phenyl isocyanate, and then compound (A3) was converted to the corresponding cyclic semicarbazide (A4) in presence of 30% of sodium hydroxide. After that, 2- (4-phenyl-1,2,4-triazine-3-one) thio benzoxazole (A4) introduced in the reaction with different alkyl halides and benzoyl chloride to synthesized the corresponding (A5-A12)compounds respectively. Structure of all the prepared compounds confirmation were proved using (FT-IR), (1H-NMR) and (13C-NMR) spectra in addition to melting points.
The title compound was obtained by reactingbenzimidazole (1.18 g, 0.01 mol) with benzyl chloride (1.25 g, 0.01 mol) andpotassium carbonate (1.38 g, 0.01 mol) in acetone (50 ml). The reactionmixture was refluxed for 10 h. After removal of the solvents, the residue wasdispersed in water to obtain an oil layer. Then the oil was dissolved in hotethanol/water (2:1) and colourless blocks of (I) arose.
68. Shin D, Lee SC, Heo YS, Lee WY, Cho YS, Kim YE. . Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. 2007;17:5686-9
78. Yngve U, Soderman P, Svensson M, Rosqvist S, Arvidsson PI. Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold. 2012;9:2442-52
Benil--monoxime thiosemicarbazone (BMOT) and 1-phenyl-1,2-propane dione-2-oxime thiosemicarbazone (PPDOT), a novel class of oxime thiosemicarbazones have been synthesized and characterized using IR, NMR and mass spectral data. PPDOT has been used for the spectrophotometric determination of copper(II). The reagents give yellow colour with copper(II) in sodium acetate acetic acid buffers. The molar absorptivity and Sandell’s sensitivity of Cu-BMOT and Cu-PPDOT are 2.2104 and 0.58104 L mol1 cm1g cm2, respectively. This method is successfully applied for determination of Cu(II) in edible oils and seeds.
95. Vasdev N, Garcia A, Stableford WT, Young AB, Meyer JH, Houle S. . Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies. 2005;15:5270-3
146. Hicks JW, Wilson AA, Rubie EA, Woodgett JR, Houle S, Vasdev N. Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [11C-carbonyl] AR-A014418 by [11C]CO2 fixation. 2012;22:2099-101