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Biological activities of benzothiazole derivatives:

CONCLUSION: This review shows that 2-substituted benzothiazoles own a wide spectrum of biological activities. The benzothiazole substituted quinol ethers and esters, substituted 2-(4-amino phenyl) benzothiazoles and 2-carbonitrile, 4-thiazolidinone and and phthalimide linked benzothizoles are having specifically awesome antitumor activity. Significant antibacterial activity is displayed by some novel triazole, oxadiazole and pyrimidine derivatives of benzothiazoles. Various 2-substituted benzothiazoles are found to have potent anti-inflammatory activity. An interesting anticonvulsant activity is demonstrated by a number of azetidine2-one and semicarbazone analogues of benzothiazole. The 2-hydrazino benzothiazoles are found to be active as antitubercular agents, whereas biphenyl benzothiazole-2-carboxamide is showing carbonic anhydrase inhibitory action.

(26) "Marihuana" means the plant Cannabis sativa L., whether growing or not, the seeds of that plant, and every compound, manufacture, salt, derivative, mixture, or preparation of that plant or its seeds. The term does not include:

COMMON METHODS TO SYNTHESIZE BENZOTHIAZOLE DERIVATIVES AND THEIR MEDICINAL SIGNIFICANCE: A REVIEW
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acyclic carbamates) and their derivatives and salts thereof (excl.

(C) intended to affect the structure or function of the body of man or animals but is not food; or
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(iii) a salt, compound, derivative, or preparation of a salt, compound, or derivative that is chemically equivalent or identical to a substance described by Subparagraph (i) or (ii), other than decocainized coca leaves or extractions of coca leaves that do not contain cocaine or ecgonine; and

(B) a salt, compound, isomer, derivative, or preparation of a substance that is chemically equivalent or identical to a substance described by Paragraph (A), other than the isoquinoline alkaloids of opium;

cyclic carbamates), their derivatives and salts thereof (excl.

(A) Opium and opiate not listed in Penalty Group 3 or 4, and a salt, compound, derivative, or preparation of opium or opiate, other than thebaine derived butorphanol, nalmefene and its salts, naloxone and its salts, and naltrexone and its salts, but including:

Shah VH, Trivedi BH. Synthesis of some benzothiazole derivative. Indian Drugs 2000;29:262-4.
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(f) Antileshmanial and Antischistosomicidal activity: Acridone derivatives of benzothiazole were synthesized and evaluated for antileshmanial activity towards Leishmania promastigotes. Two derivatives, 4-(6- nitro- benzothiazol-2- ylamino)- 10H- acridin- 9- one (2.42) and 1-(6-amino-benzothiazol-2-ylamino)-10-H-acridine-9-one (2.43) revealed a selective antileishmanial activity. The prersence of a 6-amino benzothiazole group on position 2-amino chain and a 6-nitro benzothiazole group on position 4 amino chain was found essential for antiamastigote properties 83.

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See Chapter Note 4 for a definition of newsprint.


we report the synthesis of benzothiazole ..

(c) Antihelmentic activity: Some fluoro benzothiazole Schiff bases (2.36) and sulfonamido pyrazole derivatives of fluorobenzothiazoles (2.37) were prepared and examined for anthelmintic activity against earthworm Perituma posthuma. Some of the analogs showed significant activity 79, 80.

Synthesis and electroluminescence properties of benzothiazole ..

Abstract: Various substituted 3,4 -dihydropyrimidin-2(1H)-thiones have been synthesized by conventional heating method. 2—amino thiadizole was condensed with substituted derivatives of 3,4 -dihydropyrimidin-2(1H)-thiones to get the final product. Synthesized compounds were characterized by IR, GCMS and NMR mass spectral data.

Synthesis and Characterization of Benzothiazol ..

Triazole anlogs of benzothiazole (2.35) were synthesized and screened for anti-tubercular activity against M. tuberculosis H37Rv strain and antimicrobial activity against some Gram positive and negative bacteria and fungal species. The 4-Cl analogue with MIC 25 µg/ml was revealed better anti-tubercular agent than Rifampicin (MIC 40 µg/ml) 78.

synthesis of phthalic imide derivative (benzothiazole ..

A new series of 2-substituted benzothiazole derivatives was prepared by Shashank and co-workers. All synthesized compounds were evaluated for anti-inflammatory activity and (3.2) and (3.3) were found to be the most active among the series. The maximum activity may be due to presence of –F and –OCH3 groups. The same series of compounds also showed good anticancer activity 86.

Synthesis of some new benzothiazole derivatives as ..

Objective: A series of 2-aryl substituted benzothiazole was designed and synthesized with various substituted benzoic acid. 2-mercaptobenzothiazole and thionyl chloride also used to get carbothiaote. The present study was carried to assess the pharmacological potential towards antioxidant activity of 2-aryl substituted benzothiazole derivatives.

Synthesis and structural studies of novel benzothiazole derivative …

Katz et al synthesized some derivatives of 2-hydrazinobenzothiazole (2.34) and evaluated them for anti-tuberculous activity 77.

Preparation method of 2-acyl benzothiazole derivative

Conclusion: These indicate that benzothiazole derivatives showed the defence mechanism to prevent formation of excess free radicals.

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