CONCLUSION: This review shows that 2-substituted benzothiazoles own a wide spectrum of biological activities. The benzothiazole substituted quinol ethers and esters, substituted 2-(4-amino phenyl) benzothiazoles and 2-carbonitrile, 4-thiazolidinone and and phthalimide linked benzothizoles are having specifically awesome antitumor activity. Significant antibacterial activity is displayed by some novel triazole, oxadiazole and pyrimidine derivatives of benzothiazoles. Various 2-substituted benzothiazoles are found to have potent anti-inflammatory activity. An interesting anticonvulsant activity is demonstrated by a number of azetidine2-one and semicarbazone analogues of benzothiazole. The 2-hydrazino benzothiazoles are found to be active as antitubercular agents, whereas biphenyl benzothiazole-2-carboxamide is showing carbonic anhydrase inhibitory action.
(26) "Marihuana" means the plant Cannabis sativa L., whether growing or not, the seeds of that plant, and every compound, manufacture, salt, derivative, mixture, or preparation of that plant or its seeds. The term does not include:
(iii) a salt, compound, derivative, or preparation of a salt, compound, or derivative that is chemically equivalent or identical to a substance described by Subparagraph (i) or (ii), other than decocainized coca leaves or extractions of coca leaves that do not contain cocaine or ecgonine; and
(B) a salt, compound, isomer, derivative, or preparation of a substance that is chemically equivalent or identical to a substance described by Paragraph (A), other than the isoquinoline alkaloids of opium;
(A) Opium and opiate not listed in Penalty Group 3 or 4, and a salt, compound, derivative, or preparation of opium or opiate, other than thebaine derived butorphanol, nalmefene and its salts, naloxone and its salts, and naltrexone and its salts, but including:
(f) Antileshmanial and Antischistosomicidal activity: Acridone derivatives of benzothiazole were synthesized and evaluated for antileshmanial activity towards Leishmania promastigotes. Two derivatives, 4-(6- nitro- benzothiazol-2- ylamino)- 10H- acridin- 9- one (2.42) and 1-(6-amino-benzothiazol-2-ylamino)-10-H-acridine-9-one (2.43) revealed a selective antileishmanial activity. The prersence of a 6-amino benzothiazole group on position 2-amino chain and a 6-nitro benzothiazole group on position 4 amino chain was found essential for antiamastigote properties 83.
(c) Antihelmentic activity: Some fluoro benzothiazole Schiff bases (2.36) and sulfonamido pyrazole derivatives of fluorobenzothiazoles (2.37) were prepared and examined for anthelmintic activity against earthworm Perituma posthuma. Some of the analogs showed significant activity 79, 80.
Abstract: Various substituted 3,4 -dihydropyrimidin-2(1H)-thiones have been synthesized by conventional heating method. 2—amino thiadizole was condensed with substituted derivatives of 3,4 -dihydropyrimidin-2(1H)-thiones to get the final product. Synthesized compounds were characterized by IR, GCMS and NMR mass spectral data.
Triazole anlogs of benzothiazole (2.35) were synthesized and screened for anti-tubercular activity against M. tuberculosis H37Rv strain and antimicrobial activity against some Gram positive and negative bacteria and fungal species. The 4-Cl analogue with MIC 25 µg/ml was revealed better anti-tubercular agent than Rifampicin (MIC 40 µg/ml) 78.
A new series of 2-substituted benzothiazole derivatives was prepared by Shashank and co-workers. All synthesized compounds were evaluated for anti-inflammatory activity and (3.2) and (3.3) were found to be the most active among the series. The maximum activity may be due to presence of –F and –OCH3 groups. The same series of compounds also showed good anticancer activity 86.
Objective: A series of 2-aryl substituted benzothiazole was designed and synthesized with various substituted benzoic acid. 2-mercaptobenzothiazole and thionyl chloride also used to get carbothiaote. The present study was carried to assess the pharmacological potential towards antioxidant activity of 2-aryl substituted benzothiazole derivatives.
Katz et al synthesized some derivatives of 2-hydrazinobenzothiazole (2.34) and evaluated them for anti-tuberculous activity 77.
Conclusion: These indicate that benzothiazole derivatives showed the defence mechanism to prevent formation of excess free radicals.