Davis D, Safe S (1989) Dose–response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo--dioxin. , 48:35–43.
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A., Expedient synthesis of 1,2,3-triazole-fused tetracyclic compounds by intramolecular Huisgen (click) reactions on carbohydrate-derived azido-alkynes.
S.; Jahed, N.; Golas, P.; Matyjaszewski, K., Gradient Polymer Elution Chromatographic Analysis of α,ω-Dihydroxypolystyrene Synthesized via ATRP and Click Chemistry.
M., Regioselective synthesis of [1,2,3]-triazoles catalyzed by Cu(I) generated in situ from Cu(0) nanosize activated powder and amine hydrochloride salts.
Synthesis and Supramolecular Structures of N3P3(N(Me)N=CHC6F5)6, -N3P3(C12H8O2)(N(Me)N=CHC6F5)4, and -N3P3(C12H8O2)2(N(Me)N=CHC6F5)2.
Synthesis of Azide/Alkyne-Terminal Polymers and Application for Surface Functionalisation through a [2 + 3] Huisgen Cycloaddition Process, "Click Chemistry".
Synthesis of Enantiomerically Pure α-[4-(1-Substituted)-1,2,3-triazol-4-yl]-benzylacetamides via Microwave-Assisted Click Chemistry: Towards New Potential Antimicrobial Agents.
In addition, the methyl sulfone PCBs have been shown to inhibit the CYP11B enzyme activity in the adrenals of mice and grey seals (). This type of mechanism could explain the observed modulation of glucocorticoid synthesis (Johansson et al., 1998a,b). Furthermore, reproductive toxicity, interaction with the estrogen receptor, and pulmonary metabolism have been observed after exposure to methyl sulfone PCBs (Letcher et al., 2000).
Synthesis of DOTA-Conjugated Multivalent Cyclic-RGD Peptide Dendrimers via 1,3-Dipolar Cycloaddition and their Biological Evaluation: Implications for Tumor Targeting and Tumor Imaging Purposes.
B., Synthesis of azide-alkyne fragments for click' chemical applications; formation of oligomers from orthogonally protected trialkylsilyl-propargyl azides and propargyl alcohols.
testing in eukaryotic organisms resulted in negative mutagenic responses in Chinese hamster V79 cells (Hattula, 1985). Results with Aroclor 1254 in human lymphocytes are inconclusive, because Hoopingarner et al. (1972) found no evidence of chromosomal damage at a concentration of 100 μg/ml, whereas Sargent et al. (1989) observed chromosomal damage at a concentration of 1.1 μg/ml using Aroclor 1254. Aroclor 1254 induced DNA damage in rat liver cells in culture as judged by an increase in unscheduled DNA synthesis (Althaus et al., 1982). However, whether the genotoxic doses also caused cytotoxicity was not stated.
L.; Struthers, H.; Brans, L.; Anguelov, T.; Schweinsberg, C.; Maes, V.; Tourwe, D.; Schibli, R., "Click to Chelate": Synthesis and Installation of Metal Chelates into Biomolecules in a Single Step.
R., Activity-Based Protein Profiling Reagents for Protein Arginine Deaminase 4 (PAD4): Synthesis and in vitro Evaluation of a Fluorescently Labeled Probe.
Synthesis of Functionalized NMP Initiators for Click Chemistry: a Versatile Method for the Preparation of Functionalized Polymers and Block Copolymers.