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278, 24994 (2003); Roesser, JR.

In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract.

Calcitonin, a 32-amino acid peptide hormone, is essential for calcium balance, whereas CGRP and ADM are important for neurotransmission and cardiovascular and respiratory function.

* Future pathologists: Mucoprotein in the ducts of sweatglands is a tipoff to myxedema.

261, 15524 (1986); Felsenfeld, A.

An increase in the serum calcium level is known to stimulate calcitonin secretion.

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AB - IT has been proposed that the physiological action of calcitonin is to prevent or diminish postprandial hypercalcaemia1. This is accomplished by inhibition of bone resorption2, of the tubular reabsorption of calcium3, and of the intestinal absorption of calcium4. Secretion or release of the hormone by parafollicular cells of the thyroid gland is mediated by calcium5-7 and by gastrointestinal hormones including gastrin and pancreozymin8,9. Secretion is apparently influenced by the adenylate cyclase system 7,10 and hormonal regulation presumably is mediated by cyclic adenosine 3′, 5′-monophosphate (cyclic AMP).

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N2 - IT has been proposed that the physiological action of calcitonin is to prevent or diminish postprandial hypercalcaemia1. This is accomplished by inhibition of bone resorption2, of the tubular reabsorption of calcium3, and of the intestinal absorption of calcium4. Secretion or release of the hormone by parafollicular cells of the thyroid gland is mediated by calcium5-7 and by gastrointestinal hormones including gastrin and pancreozymin8,9. Secretion is apparently influenced by the adenylate cyclase system 7,10 and hormonal regulation presumably is mediated by cyclic adenosine 3′, 5′-monophosphate (cyclic AMP).

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IT has been proposed that the physiological action of calcitonin is to prevent or diminish postprandial hypercalcaemia1. This is accomplished by inhibition of bone resorption2, of the tubular reabsorption of calcium3, and of the intestinal absorption of calcium4. Secretion or release of the hormone by parafollicular cells of the thyroid gland is mediated by calcium5-7 and by gastrointestinal hormones including gastrin and pancreozymin8,9. Secretion is apparently influenced by the adenylate cyclase system 7,10 and hormonal regulation presumably is mediated by cyclic adenosine 3′, 5′-monophosphate (cyclic AMP).

All the latest content is available, no embargo periods.

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