According to Wikipedia, fluoride salts are commonly used in biological assay processing to inhibit the activity of phosphatases, such as serine/threoninephosphatases. Fluoride mimics the nucleophilic hydroxide ion in these enzymes' active sites. Beryllium fluoride and aluminium fluoride are also used as phosphatase inhibitors, since these compounds are structural mimics of the phosphate group and can act as analogues of the transition state of the reaction. Diethyl fluoromalonate can be used to various synthesize enzyme inhibitors.
Diethyl fluoromalonate can also be used to prepare fluoride-containing amino acids, fluoride-containing Chalcone, fluorotetrahydroquinolines, and sedative areas.
Environmental friendly and risk free
Banff Green Technoligies, Inc.'s novel manufacturing process is much more environmental friendly than the traditional process. The traditional process emits HF which is extremely toxic and corrosive and a mixture of methylbenzene and triethylamine which are also toxic and difficult to contain. In contrast, Banff Green Technoligies, Inc.'s process does not involve any of these materials. Thus, Banff Green Technoligies, Inc.'s wastes can be easily treated and reach the emission standard.
Banff Green Technoligies, Inc.'s diethyl fluoromalonate can reach as high as 99% purity (by GC), and is the highest assay that is commercially available. The common purity of diethyl fluoromalonate on the market is about 90% and it is difficult to further purify.
As diethyl fluoromalonate is one of Banff Green Technoligies, Inc.’s most important products, a large stock is available all year round.
If you need quotation or price for diethyl fluoromalonate, please kindly send inquiry to us. Information as MSDS, COA, GC and NMR spectrum are all available upon your request.
Diethyl fluoromalonate is an important intermediate for the synthesis of environment-friendly fungicide Fluoxastrobin developed by Bayer CropScience in 2005. Fluoxastrobin, commonly used in Fandango, Fortix, Scenic, DISARM, EVITO, and HEC 480 SC (trade names), is a new strobilurin fungicide active ingredient for the control of fungal diseases such as early blight, late blight, leaf spots, leaf rust, and Rhizoctonia solani.
Diethyl malonate, a colourless, fragrant liquid boiling at 199 C, is prepared by the reaction of monochloroacetatic acid with methanol, carbon monoxide or by the reaction cyanoacetic acid (the half nitriled-malonic acid) with ethyl alcohol.
The methylene groups in 1,3-dicarboxylic acid utilize the synthesis of barbiturates; a hydrogen atom is removed by sodium ethoxide, and the derivative reacts with an alkyl halide to form a diethyl alkylmalonate.
Diethyl fluoromalonate, CAS number 685-88-1, is an organic intermediate widely used in the fields of pharmaceuticals, agricultural chemicals, materials, dyestuff, industrial additives, etc. It is also known as , 1,3-diethyl 2-fluoropropanedioate, 2-fluoro-malonic acid diethyl ester, fluoromalonic acid diethyl ester, Ethyl fluoromalonate, etc.
The term does not include a location where a practitioner dispenses a controlled substance on an outpatient basis unless the controlled substance is stored at that location.(43) "Production" includes the manufacturing, planting, cultivating, growing, or harvesting of a controlled substance.(44) "Raw material" means a compound, material, substance, or equipment used or intended for use, alone or in any combination, in manufacturing a controlled substance.(45) "Registrant" means a person who has a current Federal Drug Enforcement Administration registration number.(46) "Substitution" means the dispensing of a drug or a brand of drug other than that which is ordered or prescribed.(47) "Official prescription form" means a prescription form that contains the prescription information required by Section .(48) "Ultimate user" means a person who has lawfully obtained and possesses a controlled substance for the person's own use, for the use of a member of the person's household, or for administering to an animal owned by the person or by a member of the person's household.(49) "Adulterant or dilutant" means any material that increases the bulk or quantity of a controlled substance, regardless of its effect on the chemical activity of the controlled substance.(50) "Abuse unit" means:(A) except as provided by Paragraph (B):(i) a single unit on or in any adulterant, dilutant, or similar carrier medium, including marked or perforated blotter paper, a tablet, gelatin wafer, sugar cube, or stamp, or other medium that contains any amount of a controlled substance listed in Penalty Group 1-A, if the unit is commonly used in abuse of that substance; or(ii) each quarter-inch square section of paper, if the adulterant, dilutant, or carrier medium is paper not marked or perforated into individual abuse units; or(B) if the controlled substance is in liquid or solid form, 40 micrograms of the controlled substance including any adulterant or dilutant.(51) "Chemical precursor" means:(A) Methylamine;(B) Ethylamine;(C) D-lysergic acid;(D) Ergotamine tartrate;(E) Diethyl malonate;(F) Malonic acid;(G) Ethyl malonate;(H) Barbituric acid;(I) Piperidine;(J) N-acetylanthranilic acid;(K) Pyrrolidine;(L) Phenylacetic acid;(M) Anthranilic acid;(N) Ephedrine;(O) Pseudoephedrine;(P) Norpseudoephedrine; or(Q) Phenylpropanolamine.(52) "Department" means the Department of Public Safety.(53) "Chemical laboratory apparatus" means any item of equipment designed, made, or adapted to manufacture a controlled substance or a controlled substance analogue, including:(A) a condenser;(B) a distilling apparatus;(C) a vacuum drier;(D) a three-neck or distilling flask;(E) a tableting machine;(F) an encapsulating machine;(G) a filter, Buchner, or separatory funnel;(H) an Erlenmeyer, two-neck, or single-neck flask;(I) a round-bottom, Florence, thermometer, or filtering flask;(J) a Soxhlet extractor;(K) a transformer;(L) a flask heater;(M) a heating mantel; or(N) an adaptor tube.(54) "Health information exchange" means an organization that:(A) assists in the transmission or receipt of health-related information among organizations transmitting or receiving the information according to nationally recognized standards and under an express written agreement;(B) as a primary business function, compiles or organizes health-related information that is designed to be securely transmitted by the organization among physicians, health care providers, or entities within a region, state, community, or hospital system; or(C) assists in the transmission or receipt of electronic health-related information among physicians, health care providers, or entities within:(i) a hospital system;(ii) a physician organization;(iii) a health care collaborative, as defined by Section , Insurance Code;(iv) an accountable care organization participating in the Pioneer Model under the initiative by the Innovation Center of the Centers for Medicare and Medicaid Services; or(v) an accountable care organization participating in the Medicare shared savings program under 42 U.S.C.
The already known key applications of Diethyl fluoromalonate include: used as pharmaceutical intermediate, in synthesizing fungicides, special materials, dyestuff, enzyme inhibitors, fluoride-containing amino acids, fluoride-containing Chalcone, sedative, etc. The research and industrialization of diethyl fluoromalonate is still at the beginning stage, and more applications will be explored in the future.
Diethyl fluoromalonate has been shown to be a valuable intermediate in the synthesis of alpha-fluoroalkanoic acids, including y-fluoroglutamic acid. It is also an intermediate for (CAS 675-21-8) compounds, which shows good bioactivities for anti-cancer, antibacterial effects.