described the mechanism of the regulation of lipogenesis by fatty acids in measuring the rate of synthesis of fatty acid synthase in mouse liver ().
Holman RT et al.
showed that it is formed from acetateduring the normal course of cholesterol biosynthesis in rat liver homogenates (, J Biol Chem 1981, 256, 1067).
First description of the possibility of curing neuropsychiatric disorders with adiet enriched in linolenic acid (flaxseed oil) ().
Eberhard A et al.
Thatacidic lipid was later shown to be a universal component of photosynthetictissues.
Hirsch J reported the reversed-phase separation of non polar lipids on a columnof polymerized vegetable oil (Factice) ().
Klenk E et al.
The first component protein of an enzyme of fatty acid biosynthesis, fatty acidsynthase, was purified ().
Polyprenol diphosphates were shown to be involved in the biosynthesis ofpolysaccharides in () and in the biosynthesis of peptidoglycans in ().
The structure of juvenile hormone of insects was elucidated by Roller H ().
1961, 83, 3080) made the first total synthesis of arachidonic acid.
Imai J demonstrated that the oxidative desaturation of a saturated fatty acid (palmitic acid) is depressed in diabetic rats ().
Kennedy EP described the general pathways of the glycerolipid biosynthesis in animal cells ().
Bremer J et al.
of the synthesisof oleic acid ().
Klenk E identified sphingomyelin as the stored phospholipid in cells frompatients with Niemann-Pick disease ().
Von Euler US identified a lipid-soluble substance from semen which stimulatesuterine smooth muscle contraction and named it prostaglandin ()
discovered the essentiality of thelong-chain polyunsaturated fatty acids (linoleic and linolenic acids) ().
Anderson RJ reported the presence of inositol in lipids of tubercle bacilli ().
First demonstration of the biosynthesis of vitamin A from
of the antioxidant properties of tocopherols ().
First synthesis of linoleic acid ()
Kurz H used ethyl alcohol to derivatize fatty acids (FA ethyl esters) beforetheir analysis ().
First data on cholesterol and fatty acid metabolism after using an isotope of hydrogen(deuterium) in mice and chicks ().
Using deuterated acetate, Sonderhoff R et al. have shown that it serves asa precursor for sterols including ergosterol in yeast ().
Paul Karrer received the
of the right structures of linoleic and arachidonic acids ().
Dam H and Doisy EA received the Nobel prize in Physiology or Medicine for the discovery of vitamin K, its pure preparation, the determination of its chemical structure and the synthetic production of that vitamin.
Cramer DL et al.
described for the first time the synthesis of a naturalneutral lipid, tributyrin, by the direct esterification of glycerol and butyricacid ().
described the first synthesis of linoleic acid () and linolenic acid ().
Reiser R demonstrated that the high levels of saturated fatty acids in ruminantanimal fat are due to the hydrogenation of the dietary unsaturated fatty acidsin the rumen ().
Asselineau J elucidated the structure of mycolic acids (
Isovaleric acid is clear colorless liquid that is sparingly soluble in water, but well soluble in most common organic solvents.; It has been suggested that isovaleric acid from pilot whales, a species frequently consumed in the Faroe Islands, may be the unusual dietary factor in prolonged gestation in the population of the Faroe Islands.; Previous studies suggested that was due to the high intake of n-3 polyunsaturated fatty acids has been, but fatty acid data for eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA) in blood lipids of Faroese and Norwegians was reviewed in terms of the type of fish eaten (mostly lean white fish with DHA much greater than EPA); the popular lean fish, thus, probably provides too little EPA to produce a marked effect on human biochemistry.
purified a phospholipid (phosphatidylcholine) from egg yolk onan alumina column ().
Baer E described the synthesis of phosphatidic acid by treatment ofdiacylglycerol with diphenylchlorophosphate and removal of the phenyl group bycatalytic reduction ().
Hofman K et al.