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Synthesis of oxazolidinones - Organic chemistry

In recent years, the chemistry of triazoles and their fused heterocyclic derivatives has received considerable attention owing to their synthetic and effective biological importance.

D. R. Rogue et al, 37 have synthesized 1, 2, 3-Triazoles (18), were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solvent-less conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1, 2, 3-triazole products bear functionality that may be readily derivatized.

1,2-Amino Alcohols and Their Heterocyclic Derivatives …
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Synthesis of N -Heterocycles - Organic chemistry

synthesis and biological significances of 1, 2, 4-triazole and its derivatives: a review html full text
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Saini MS and Dwivedi J: A Review: Synthesis and Biological significances of 1, 2, 4-triazole and its derivatives. Int J Pharm Sci Res 2013: 4(8); 2866-2879. doi: 10.13040/IJPSR. 0975-8232.4(8).2866-79

S. Moreau et al, 72reported the synthesis of 3-amino-7- (2, 6-dichlorobenzyl)-6-methyl triazolo[4, 3-b]pyridine derivatives (37) of amide and carboxylic acid and investigated for their anticonvulsant potency

PDF Downloads : Oriental Journal of Chemistry

Rebecca Hluhanich et al, 62 synthesized Various derivatives of trisubstituted triazoles (24) were prepared as inhibitors of reverse transcriptase and the two derivatives with difference in thio group position were found out to be most active compounds .

1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis
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Anti-inflammatory Activity: Mohammad et al, 46 synthesized a series of 1, 3, 4-oxadiazole [6a-6b] and 1, 2, 4-triazole [6c] derivatives of 4-hydroxyphenyl acetic acid and evaluated for their anti-inflammatory activity by carrageenan induced rat paw edema method. The compounds, which showed good anti-inflammatory activity, were screened for their ulcerogenic and lipid peroxidation activities.

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Chapter 20:Antimicrobial Drugs Flashcards | Quizlet

The Journal of Organic Chemistry (ACS Publications)

Antibacterial: Bacteria are the simplest and smallest unicellular organisms found individually or in clusters. The multitude of highly effective and relatively non-toxic drugs available for the treatment of bacterial infections has provided tough competition for the medicinal chemist, attempting synthesis of new antibacterial agents. The medicinal chemistry is towards its advancement, many antibiotics are now chemically modified from original compounds present naturally e.g. beta lactams 38 and named as amino glycosides and a lot more are synthetically derived as sulfonamides 39, the quinolones and the oxazolidinones.

Diels–Alder reaction - Wikipedia

ABSTRACT: In the last few decades, to synthesize the different new heterocyclic compounds along their derivatives which were evaluated for their biological activities as antimicrobial, antiviral, antitumor, anticonvulsant, antifungal, the triazole moiety seems to be very small but in the biological profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. In this review we provides a brief response of the medicinal chemistry of 1, 2, 4-triazole and its derivatives. A literature survey of procedures for the preparation of 1, 2, 4-triazole and 1, 2, 3-triazoles is presented by generalized synthetic method.

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Treatment ofthese oxazolidinones benzo thiazinen deravatives withmethanesulfonyl gives its sulphonates derivatives on further treatmentwih sodium azide and tri phenyl phosphine in acetic anhydride to giveits acetamide derivatives.

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T1 - Toward design of a practical methodology for stereocontrolled synthesis of χ-constrained pyroglutamic acids and related compounds. Virtually complete control of simple diastereoselectivity in the Michael addition reactions of glycine Ni(II) complexes with N-(enoyl)oxazolidinones

Daptomycin versus Standard Therapy for Bacteremia …

R.K. Mali et al, 52synthesized 5-(N-substituted carboxamidomethylthio)–3-(3'-pyridyl) - 1, 2, 4-triazole (90) derivatives (14). Anti-fungal activity was carried out against C. albicans and A. niger at the concentrations of 50 and 100 μg/mL using Fluconazole as the standard.

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