284. Suzuki K, Satake M, Suwada J, Oshikiri S, Ashino H, Dozono H. . Synthesis and evaluation of a novel (68)Ga-chelate-conjugated bisphosphonate as a bone-seeking agent for PET imaging. 2011;38:1011-8
144. Fellner M, Baum RP, Kubicek V, Hermann P, Lukes I, Prasad V. . PET/CT imaging of osteoblastic bone metastases with Ga-68-bisphosphonates: first human study. 2010;37:834
22, 2013) by Yelm et al., assigned to Procter & Gamble, entitled SYNTHESIS OF CYCLOHEXANE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS, a series of Neomenthyl esters and ethers were disclosed that had cooling properties as good as, or better, than the coresponding menthyl isomers.
The most common and commercially available BFC comprise esters (-nitrophenyl, pentafluorophenyl, -hydroxysuccinimide, sulfo--hydroxysuccinimide), isothiocyanates, maleimides, hydrazides, α-haloamides for the reaction with nucleophilic functional groups (-NH2, -SH, -OH) of vector molecules and formation of amide, urea, thiourea, Schiff-base, or thioester bond . Methods have been developed for the conjugation with peptides by solid-phase peptide synthesis (SPPS) resulting in defined position and number of chelate moieties. The outcome of the conjugation in solution wherein peptides and proteins comprise several reactive sites is very often a mixture of bioconjugate molecules with various content of the chelator. Such heterogeneity may cause the interpretation ambiguity of the performance of such imaging agents. Regioselective conjugation to antibodies was achieved by enzymatic reaction with lysine and glutamine residues using bacterial and human tissue transglutaminase as catalysts .
Esters are formed byacid-catalysed esterification with azeotropic distillation of water orby direct synthesis in which the appropriate ester of monochloroaceticacid is reacted with dichlorophenol to form the 2,4-D ester.
134. Knor S, Modlinger A, Poethko T, Schottelius M, Wester HJ, Kessler H. Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds. 2007;13:6082-90
Major components was apiol (22.64%) followed by (3-Methoxy-nitrophenyl) acetic acid, methyl ester (8.14%), phytol (7.47%), n-hexadeconoic acid (7.29%), E-2-tetradecen-1-ol (6.92%), 5H-cyclopropa (3,4) benz (1,2-e) azulen-5-one, 4,9,9a- tris(acetyloxy)-3-[(acetyloxy)methyl]- (5.89%), stigmasterol (4.60%), 3,7,11,15-tetramethyl-2-hexadecen-1-ol (4.00%), campesterol (3.19%), a- sitosterol (2.92%), 9,12,15-octadecatrienoic acid, (Z,Z,Z)- (2.79%), Z,Z- 2,5-pentadecadien-1-ol (2.53%) and 3-hydroxy-4-methoxycinnamic acid (2.01%).
285. Ogawa K, Takai K, Kanbara H, Kiwada T, Kitamura Y, Shiba K. . Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent. 2011;38:631-6