This module introduces essential principles and concepts in chemistry, including atomic structure, electronic structure of atoms, chemical bonding, stoichiometry of reactions, measures of concentration, oxidation states and redox chemistry, acids and bases, and an introduction to organic chemistry.
This module expands upon topics covered in SEF003 and provides a further introduction to the fundamentals of chemistry; including topics such as thermochemistry, reaction kinetics and equilibria, molecular structure, aspects of organic chemistry, and spectroscopic methods. Prerequisite: SEF003 Introductory Chemistry
This module is concerned with the principles of drug design, drug discovery and the relationship between the molecular structure of drugs and their biological activity. Topics to be covered include: how candidate drug structures are selected for synthesis, structure activity relationships, physico-chemical properties of compounds and how these may be employed to assist in the selection of drug candidates, organic synthetic methods that are of particular relevance to the preparation of drug-like molecules. The module will build upon the knowledge and understanding of pharmaceutical chemistry gained in CHE206, and examines applications of the drug discovery process by focusing on specific disease areas such as cancer, where concepts and methods of current therapies and the structures and mechanisms of action of chemotherapeutic agents are studied.
This module is concerned with the principles of drug design, drug discovery and the relationship between the molecular structure of drugs and their biological activity. Topics to be covered include: how candidate drug structures are selected for synthesis, structure activity relationships, physico-chemical properties of compounds and how these may be employed to assist in the selection of drug candidates, organic synthetic methods that are of particular relevance to the preparation of drug-like molecules.
This module focuses on the role of organic compounds in the natural world, with particular reference to biological and pharmaceutical systems. The role of synthetic models for biological systems is examined critically. The aim is to rationalise the properties and reactivity of the principal classes of natural products and to demonstrate the fundamental chemistry behind biochemical reactions in biosynthetic pathways. Major biosynthetic pathways leading to the formation of secondary metabolites are examined from the mechanistic point of view.
This module is designed to introduce first year students to the properties of the different phases of matter (gases, liquids and solids), and to the theory and practise of analytical chemistry viewed from a physical and inorganic chemistry perspective. The module considers the various types of interactions that occur between atoms and molecules, and how these influence the molecular behaviour and the characteristics of the various phases of matter. The review of solid structures includes an introduction to crystallography and diffraction. The introduction to analytical chemistry will cover topics such as sample preparation, qualitative tests, gravimetric and combustion analysis, electroanalytical chemistry, an introduction to mass spectrometry and the basics of separation science, including GC and HLPC.
Most of the teaching will be via small-group tutorials where students will develop an appreciation and experience in various aspects of communication in biochemical science. The module will focus on types and structure of scientific literature, as well as types of journals and the process of peer review. Tutorials will cover approaches to effective short essay writing and delivering scientific talks. Attendance at research seminars is required and a library workshop to developing literature search skills. Tutorials will require a high level of student participation. A number of essays and other course will set and assessment for the module will be Coursework (60%) Final Exam (40%).
The role of chemistry in materials science. The module will begin with the description of chemical bonding in atomic systems. Students will be given an understanding of how atomic orbitals are derived and what they actually mean. This will be used as a basis to explain group and period behavior in the periodic table. This will be developed further into molecular bond systems such as hybrid bonding (Sp3, Sp2 etc) as well as very basic descriptions of molecular orbital theory. Students will learn how to use these concepts to define molecular shape and behavior. Students will also learn how these shapes and bond types are important in chemical reactions that form materials, for example polymer synthesis. This will be done by providing a discussion on basic organic chemistry reaction mechanisms. The module will continue to show how bonding changes in materials, band theory will be introduced and described using semiconductor materials as an example. Unusual behaviors which are the result of quantum effects on bonding will also be described, for example quantum dots.
This module involves students carrying-out an original piece of experimental or computational research on projects agreed with their academic supervisor. Projects are in the areas of biological, organic, inorganic, physical, materials or theoretical/computational chemistry; or a combination thereof. The work also involves an in-depth and critical evaluation and dissemination of the relevant literature associated with the topic and methodologies employed.
A dissertation is prepared and defended in an oral examination (mid-September); students also present their work in the form of a ~15-20 min research seminar (mid-September).
The diversity of expertise of the chemistry and biochemistry faculty involved with the programme affords a wide range of project choice within the chemical sciences, in addition to facilitating identification of potential project supervisors.
The search for new drugs to treat a wide range of human ailments remain a great challenge to the pharmaceutical and biotechnology industries. Students will be given a perspective on the history of drug discovery to the present challenges in drug design. The medicinal chemistry content will provide students with an understanding of the complex biological and chemical problems that are involved in the design and synthesis of novel therapeutic agents. They will be given an in-depth analysis of the principles of identifying new compounds with the potential to be drugs, and their development for therapeutic use. Students will also be given an understanding of preclinical testing of drugs including the use of animal models for safety testing, intra and inter-species variations, detecting carcinogenicity in experimental systems and man, strategies of new initiatives in pharmaceutical development and risk assessment of pharmaceuticals. Introductory lectures will be followed by lectures in specialized areas of the subject given by experts in their field. In addition to formal lectures and interactive seminars, the course will provide tutorials with opportunities to critically-evaluate research papers. We will offer practical workshop sessions to reinforce the lectures.
The module is designed to give you a detailed understanding of stereochemistry, an appreciation of the relevance of this topic to the activity and regulatory requirements of small-molecule pharmaceuticals, and a detailed knowledge of the methods available to generate single enantiomers of pharmaceutical relevance. Furthermore the module will provide you with an overview of the principles, practicalities and applications of contemporary catalytic methodology of relevance to drug discovery and manufacture within the pharmaceutical industry. The aim is to furnish you with sufficient knowledge that you will be able to appraise and develop synthetic strategies for the synthesis of complex organic molecules using catalytic methodology.