A plasma salicylate concentration of 300 to 500 mg/L at 6 hour post-ingestion indicates a mild toxicity, 500 to 800 mg/L moderate toxicity and >800 mg/L is considered as severe SA intoxication.
He also synthesized Aspirin because his father, who had severe arthritis, could not tolerate the salicylic acid he was taking for pain relief.
The Kolbe Synthesis for the production of salicylic acid was created by the German chemist Hermann Kolbe.
Cases of salicylic acid dermal absorption which induced intoxication particularly in children have also been reported (Davies et al., 1979; Clark & Wilson, 1981).
Estimation of serial plasma salicylate poisoning following overdosage in adults revealed that the peak concentration may be delayed up to 24 hours post ingestion (Balali-Mood, 1981).
Although the clinical value of screening for salicylates in acute poisoning was emphasized (Chan et al., 1995), determination of plasma salicylate concentration is required to confirm the diagnosis and to estimate the severity of salicylate intoxication.
Chronic salicylate poisoning particularly those with metabolic acidosis, hypoglycaemia, lethargy, coma and fits in malaria endemic areas may mimic severe malaria as was investigated in Kenya (English et al., 1996).
Salicylic acid has more irritant effects on gastric mucosa than acetylsalicylic acid and thus has been withdrawn from oral administration for many years.
Ferric Chloride Test for Purity Chemical Reagents: .1M HCl, standardized
.1M NaOH, standardized
Phenolphthalein solution Step 1 Approximately .5g of the synthesized aspirin was weighed and placed into a 250mL Erlenmeyer flask.
Cigarette smoking, chronic salicylate ingestion, metabolic acidosis and the presence of neurological symptoms and signs on admission are strong risk factors for the subsequent development of pulmonary oedema.
Application of teething gels containing salicylic acid induced intoxication (Paynter & Alexandre, 1979). 9.2.4 Eye contact 9.2.5 Parenteral exposure 9.2.6 Other
Life threatening salicylate poisoning caused by percutaneous absorption of salicylic acid (10% ointment) in a 7-year-old boy with ichthyosis vulgaris was reported (German et al., 1996).
The presenting signs of chronic salicylate poisoning can include metabolic acidosis, hypoglycemia, lethargy, coma and fits (English et al., 1996). 9.2.2 Inhalation 9.2.3 Skin exposure
of HCL: .0932M
Sample Weight: .516g Volume of NaOH required to neutralize all acids present: Final buret reading: 45.50mL
Initial buret reading: 0mL
Volume of NaOH: 30.50mL
Approximate volume of NaOH to be added for hydrolysis: 45.50mL Actual volume of NaOH added for hydrolysis: Final buret reading: 15.4mL
Initial buret reading: 0mL
Volume of NaOH: 45.50mL 7 6 3 4 6 3 3 4 2 2 3 #1 #2 #3 8 4 4 2 2 Procedure 2 Explanation of Calculations (l) (aq) (aq) (aq) 0.0932 M For all three trials, we used the equation:
M V = M V
Then we rearranged the equation to solve for M by dividing by V .
In patients with significant acidosis and in patients who ingest multiple doses or sustained release preparations, the Done nomogram will tend to underestimate the severity of salicylate intoxication (Todd et al., 1981).
Acid-base disturbances are usually mixed in mild to moderate salicylate poisoning (Proudfoot & Brown, 1969; Proudfoot, 1983). 8.3.3 Haematological analyses 8.3.4 Interpretation of biomedical investigations