Depending on the day of administration, the single dose increased the IgM plaque-forming cell content of the spleen and the serum anti-sheep red blood cell antibody titre.
220.127.116.11 Organophosphorus compounds Single doses of the insecticides parathion, malathion, and dichlorvos cause significant reductions in anti-sheep red blood cell plaque-forming cell responses (Casale et al., 1983, 1984).
I told her that I have seen many people with similar complaints, but that just treating the symptoms would not be sufficient to effect a true cure. Why was it that nothing that she tried had been effective? I was willing to bet that her blood pH was too acidic or too alkaline. This has far-reaching ramifications, as the blood ceaselessly flows to all the tissues of the body, bringing with it life-giving oxygen and nutrients, and taking away metabolic wastes. The blood flows to the mucosal cells that line the intestinal tract where the candida organisms live, as well as to the liver, the muscles, the heart and the brain. If the blood pH is out of balance, this will be mirrored in the other bodily fluids (such as the lymph and intracellular fluids), as well, potentially, in all the tissues and organs of the body.
Too many sterols, or not enough fatty acids, block or clog the cell membranes, interrupting the free movement into and out of the cells. This leads to an anabolic imbalance in the cells, effectively stifling their ability to "breathe". But too few sterols, or too many fatty acids, has the opposite effect, creating an overly permeable or "leaky" membrane, with insufficient control over the movement of nutrients and wastes. This leads to a catabolic condition, comparable to cellular hyperventilation. Cellular respiration may slow down as a normal part of the anabolic phase of the 24 hour cycle, and speed up during the catabolic phase. But when either part of the cycle becomes chronically unbalanced, problems with energy production will inevitably follow, eventually manifesting as disease. By optimizing the pH of the blood through Metabolic Typing, we seek to prevent or redress any such imbalance.
A sensitive parameter of the immunotoxicity of TCDD and TCDD congeners in mice is suppression of the T cell-dependent antibody response to sheep red blood cells in mice (Vecchi et al., 1980; Davis & Safe, 1988; Kerkvliet et al., 1990).
Bill Wolcott, who founded Healthexcel, and myself have founded a Metabolic Type Testing Program that can be tested for each individual as to which diet and supplements that are best for them. This did not happen overnight but took years of research and development on patients. After years of trial and error, we have surfaced with a testing procedure, which will give us a success rate of between 80 and 90 percent of all people we test. It also affords us the opportunity of helping people who could never be helped in the past by any medical protocol. Once we learn the imbalances of each person's make up, we can then began to address various systemic problems that they are encumbered with. We never treat the disease; we treat the person with the disease by correcting the imbalances. Doing this procedure alleviates the various disease systems. One of the most crucial imbalances we focus on is the oxidative and autonomic metabolic types. This particular imbalance is the granddaddy of all other imbalances. The acid-alkalinity of the blood has to be optimized so that micro and macro nutrients can be absorbed, assimilated and utilized into our tissues at the cellular level. After we balance oxidative and autonomic systems, we then look at balancing the electrolyte, anabolic, catabolic characteristics and the alkalosis acidosis imbalances in the tissues. This is very comprehensive testing, but once it is accomplished, then patients can achieve a higher level of wellness. I would like to give you an example of a little 15-year-old girl who went through our program. I have hundreds of examples such as this and in future newsletters I will include several case histories.
The response to sheep red blood cells in the plaque-forming cell assay has been used to establish dose-response relationships for several potentially immunotoxic Aroclors in mice given a single intraperitoneal injection of PCB mixtures (Davis & Safe, 1989).
Immunological effects were reported after both 23 and 55 months of exposure and comprised significantly decreased IgM and IgG responses to sheep red blood cells at the lowest dose.
Ah receptor-dependent immunotoxicity has been demonstrated in mice for thymic atrophy and the antibody response to sheep red blood cells (Tucker et al., 1986; Kerkvliet & Burleson, 1994); however, the importance of Ah receptor-mediated events in chronic, low-level TCDD immunotoxicity is controversial (Morris et al., 1992).
Any food that is improperly broken down in the gastrointestinal (G.I.) tract has the potential to irritate the mucosa, the delicate cells that line the small and large intestines. Such irritation, if unchecked, can lead to various inflammatory or irritable bowel disorders such as "leaky gut" syndrome (more properly known as excessive intestinal permeability), Crohn's disease (inflammation of the small intestine and, sometimes, the colon), or colitis (inflammation of the colon). Eating foods that are right for one's Metabolic Type, maintaining digestive competence, and keeping the blood pH balanced will help to prevent such problems, or ameliorate them if they have already occurred.
Thus, the disappearance of lymphoid cells from bone marrow, blood, and tissue, and thymus weight may be the first and most obvious signs of toxicity, as was seen in application of the tiered approach to assessing the immunotoxicity of pesticides, mentioned previously (Vos & Krajnc, 1983; Vos et al., 1983a).
All three doses of parathion-methyl decreased the number of red blood cells and the haematocrit value, and the two highest doses decreased the leukocyte count.
She did wisely agree, however, to remain under her doctor's care so that her progress could be monitored. We then set about the process of metabolically evaluating her condition. Her medical history revealed a pattern of chronic fatigue and continuous flu-like symptoms, and she told me that she seemed to spend more time feeling ill than well. After completing our Metabolic Testing (which, at that time, included using blood tests to directly evaluate the blood pH), I discovered that her blood was 7.58, a strongly alkaline reading that significantly exceeded the optimal level of 7.46. (Although the difference between these numbers appears small, the metabolic ramifications are profound). This was preventing her body from being able to properly assimilate and utilize nutrients in her cells, tissues and organs, and she therefore had severe nutritional deficiencies, despite eating what would have normally been considered an adequate diet. Our first task, therefore, had to be to bring her pH back into the normal range, and, for this purpose, we used targeted foods and supplements that we knew would acidify her blood, in order to counteract her extreme alkalinity.