Assignments got your hair on fire?

Douse the flames with our full-range writing service!

Experienced academic writing professionals are at your fingertips. Use this handy tool to get a price estimate for your project.

Holton taxol total synthesis - WikiVisually

In 1996 the Wender Group succeeded in "total synthesis" of Taxol (meaning they figured out how to create it from scratch in the laboratory). Their work helped pave the way for Taxol—now produced via "semi-synthesis" using some material from renewable yew trees—to become the best-selling cancer-fighting drug in history, saving countless lives and leaving the scarce stands of Pacific yews intact.

In the four total syntheses to date two clearly differentstrategies have been demonstrated. Thus, Nicolaou and Danishefskyboth utilised a convergent approach to form the 'B' ring by anintramolecular cyclisation whereas both Holton and Wender used linearroutes, with the central 'ABC' ring system being formed by thefragmentation of the highly strained bicyclic systems. A commonfeature of all the syntheses is the use of a C1, C2 cyclic carbonateto introduce the hydroxybenzoate functionality. In the two convergentsyntheses the carbonate also has the added advantage of preorganisingthe structure for cyclisation.

A formal total synthesis of taxol aided by an automated synthesizer.

Patent US5416225 - Total synthesis of taxol - Google …

Key features of the structure of Taxol (Figure 1) thatrequire careful consideration by the synthetic chemist attempting atotal synthesis are, the sterically congested double bond containing'A' ring, the central eight membered 'B' ring and the oxetane 'D'ring. The high degree of oxygenation present in a range of oxidationstates, coupled with the 9 asymmetric centres means that Taxolpresents an interesting challenge to synthetic chemists.

In 1996 the Wender Group succeeded in "total synthesis ..

Versatile Services that Make Studying Easy
We write effective, thought-provoking essays from scratch
We create erudite academic research papers
We champion seasoned experts for dissertations
We make it our business to construct successful business papers
What if the quality isn’t so great?
Our writers are sourced from experts, and complete an obstacle course of testing to join our brigade. Ours is a top service in the English-speaking world.
How do I know the professor won’t find out?
Everything is confidential. So you know your student paper is wholly yours, we use CopyScape and WriteCheck to guarantee originality (never TurnItIn, which professors patrol).
What if it doesn’t meet my expectations?
Unchanged instructions afford you 10 days to request edits after our agreed due date. With 94% satisfaction, we work until your hair is comfortably cool.
Clients enjoy the breezy experience of working with us
Click to learn our proven method

Numerous examples of the total synthesis of Taxol have ..

of clients claim significantly improved grades thanks to our work.
of students agree they have more time for other things thanks to us.
Clients Speak
“I didn’t expect I’d be thanking you for actually improving my own writing, but I am. You’re like a second professor!”